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| Author(s): |
Jheniffer Queiroz Raimundo
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas |
| Defense date: | 2024-07-31 |
| Examining board members: |
Maria Francisca Colella Santos;
Maria Cecilia Marconi Pinheiro Lima;
Milaine Dominici Sanfins
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| Advisor: | Maria Francisca Colella Santos |
| Abstract | |
Introduction: COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, a new member of the coronavirus family. Although respiratory transmission is the main route, concerns have arisen regarding possible vertical transmission, which consists of the transmission of the virus from the mother to the fetus through the dissemination of viral particles in the amniotic fluid. Fetal viral infection via the placenta can influence the formation of the auditory system, leading to congenital hearing disorders. Therefore, the aim of this research was to analyze the effects of vertical exposure to COVID-19 on the auditory system of newborns. Methodology: Approved by the Research Ethics Committee, as part of a macroproject entitled "Impacts of COVID-19 on the peripheral and central auditory system of children and adolescents," opinion no. 5.454.075. The study included a Study Group (SG) and a Control Group (CG). The SG was composed of 23 infants up to one year old, whose mothers were infected with SARS-CoV-2, selected during neonatal hearing screening. The CG was composed of 15 infants whose mothers became pregnant after the end of the pandemic, with a negative COVID-19 test and no respiratory symptoms during pregnancy. The evaluations conducted for both groups were Auditory Brainstem Evoked Potentials (ABR), Tympanometry, Transient Evoked Otoacoustic Emissions (TEOAE), and Distortion Product Otoacoustic Emissions (DPOAE). This research was divided into two studies, one cross-sectional and the other longitudinal. Results: All participants exhibited absolute latency values within the normal range for their age group for waves I, III, and V. However, a statistically significant difference was observed in the latency of wave I in the left ear. A tendency for absent responses at high frequencies in TEOAE and a decrease in amplitude at high frequencies over time in TEOAE and DPOAE was identified. Conclusion: There was no evidence that vertical exposure to COVID-19 causes hearing loss, but a deterioration in the functioning of hair cells was noted (AU) | |
| FAPESP's process: | 22/13478-5 - AUDITORY EVALUATION OF INFANTS BORN TO COVID-19 POSITIVE MOTHERS DURING PREGNANCY |
| Grantee: | Jheniffer Queiroz Raimundo |
| Support Opportunities: | Scholarships in Brazil - Master |