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| Author(s): |
Glauber Campos Vale
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Piracicaba, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba |
| Defense date: | 2010-02-19 |
| Examining board members: |
Cinthia Pereira Machado Tabchoury;
Cassiano Kuchenbecker Rosing;
Josimeri Hebling Costa;
Adriana Franco Paes Leme;
Marinês Nobre dos Santos
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| Advisor: | Cinthia Pereira Machado Tabchoury |
| Abstract | |
The combination of methods of fluoride (F) use has been suggested for high caries risk individuals or groups. The additive effect of the combination of professional application of fluoride and fluoride dentifrice (FD) use achieve a modest reduction in enamel caries compared to dentifrice used alone. Nevertheless the anti-caries effect of this combination has not been studied for root dentine, which is more susceptible to caries than enamel. This study aimed to evaluate the effect of the combination of application of acidulated phosphate fluoride (APF) and DF use on root dentine demineralization, F availability in dental biofilm formed in situ as well as on reactivity products formed on root dentine. Twelve adult volunteers took a part in this crossover, double-blinded (considering the dentifrices) in situ study and wore palatal appliances containing bovine root dentine slabs with pre-determined surface hardness. The dentine slabs were subjected during four experimental phases of seven days each to a high cariogenic challenge (biofilm accumulation and sucrose solution exposure 8x/day) and to one of the following treatments: placebo dentifrice (PD), 1,100 ppm F-dentifrice (FD), APF +PD and APF + FD. The slabs of APF groups were pre-treated with APF gel (1.23% F) for 4 min at the beginning of the respective experimental phase. The dentifrices were used 3x/day. For statistical analyses, a factorial 2 x 2 was used, with the APF (applied or not) and fluoride dentifrice (yes or not) considered as study factors. The significance limit was set at 5%. Lower demineralization and higher F concentration in biofilm fluid was observed when FD was used in comparison with PD (p<0.05) and when APF application was done in relation to those groups in which APF was not applied (p<0.05).The combination of APF and use of FD showed a synergic effect on reduction of root dentine demineralization, on F availability in biofilm fluid and on the enhanced retention of reactivity products formed on dentine, suggesting that the combination of APF gel application and the daily use of F dentifrice may be relevant to control root caries. (AU) | |
| FAPESP's process: | 05/03090-4 - Fluoride influence on acidogenicity, polysaccharide concentration and genotypic diversity of mutans group streptococci in dental biofilm detected by AP-PCR: an in-situ study |
| Grantee: | Gláuber Campos Vale |
| Support Opportunities: | Scholarships in Brazil - Doctorate |