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| Author(s): |
Guilherme Garlipp Tedeschi
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas |
| Defense date: | 2012-01-31 |
| Examining board members: |
Fernando Cendes;
Florindo Stella;
Lilian Teresa Bucken Gobbi
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| Advisor: | Fernando Cendes |
| Abstract | |
Introduction: Stroke is an important disease with great implications in social and economic factors around the world, especially in Brazil, where is ranked as the first cardiovascular cause of death and the main cause of morbidity, which generates functional disability and some level of dependence on the patient. Thrombolysis with tissue plasminogen activator factor (rt-PA) on acute phase of stroke, immediately after ictus, has been widely used worldwide for the restoration of cerebral circulation in ischemic stroke, with great influence on the recovery of motor skills. There are several ways to quantify the damage incurred by stroke, including magnetic resonance imaging (MRI), which is able to provide accurate results for diagnostic and other not too explicit research results that contribute to the measurement of cell damage and its subsequent recovery. Objective: The main objective of the present study is to evaluate cortical thickness in two different periods of the stroke (Acute and Chronic) and establish associations in relation to motor function and the time of thrombolysis. Methodology: Patients (33) with ischemic stroke were evaluated with MRI and functional scales (Fugl Meyer, FIM and FAC) in two stroke stages, the acute phase with 62.67 days post-stroke and chronic phase (follow up), with 419.22 days after stroke. The time of thrombolytic treatment was divided into more than 150 minutes (Group D) and less than 150 minutes (Group A). MRI images statistical analysis were performed by the software Freesurf, Qdec tool (p < 0.05) and other analysis were performed by Systat 9. Results: The analysis of all images showed increased cortical thickness in chronic group. Same results were found at T group in the chronic phase, at A group in acute phase and at D group in the chronic phase. Increased cortical thickness was observed in specific areas (Wernicke and precentral gyrus) between acute and chronic phases. Functional gain was significant (p < 0.05) compared to the scales Fugl Meyer and FIM periods between acute and chronic (AU) | |