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| Author(s): |
Roberta Soares Lara Cassani
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Ribeirão Preto. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) |
| Defense date: | 2009-09-25 |
| Examining board members: |
Julio Sérgio Marchini;
Olga Maria Silverio Amancio;
Ana Maria Pita Lottenberg;
Carla Barbosa Nonino;
Jose Ernesto dos Santos
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| Advisor: | Julio Sérgio Marchini |
| Abstract | |
The control of subclinical inflammatory process is associated with the prevention nutritional RF (risk factor), such as dislipidemia and the increase of visceral fat deposition. Nutritional, inflammatory and metabolic indicators seem also to related to life style. The linseed has been recognized as rich in fibers and -3. However, a new component in its nutritional composition has deserved the attention for its anti- inflammatory and antioxidant roles. This component is called lignans, a complex polymer and the main non-carbohydrate constituent of vascular plants. It is binded to cellulose fibers and is responsible for reinforcing cell walls structure, preventing them from collapsing. Plant lignans, in contact with the human intestinal flora, become enterolignans, specially enterodiol and enterolactone. This present work hypothetically that the amount of dietetic plant lignans interfere in the metabolic profile, altering the risk factors involved in the nutritional health state and consequently, the welfare state. Therefore, the objective of this study is to know if different diet nutritional composition characteristics can change the inflammatory profile, independently of the presence of enterolignans from the linseed. For 42 days, 52 male volunteers, average 37±9 years old, from a industrial city of Itu-SP, were evaluated. The volunteers were divided into 4 research groups; one control group and 3 groups on isocaloric diets with different proportion of carbohydrate (CH) and the addition of powdered linseed or ground raw rice (a double blind protocol). Personal data, RF (hypertension, dislipidemia and diabetes), habits (smoking and sedentary) and family antecedents were collected. A nutritional-laboratorial evaluation was performed in order to get anthropometric data; blood pressure checked and blood samples (after 12 hours fast) for total cholesterol and fractions (LDL-c and HDL-c ), triglycerides, glycemia, insulin, Homa-beta and Homa-IR, uric acid, inflammatory indicators (Reactive-C Protein (PCR) , Tumoral Necrosis Factor (TNF-a) and Seric Isoprostane ), hormonal (Leptin and Adiponectin), enterodiol and enterolactone seric and urinary enterolignins. It was observed a reduction of the studied anthropometric measures and for the oxidative stress indicators. A significant change occurred in the anthropometric measurements and the oxidative stress marker evaluated for all groups, but no difference among them was noted. On the other hand, biochemical, inflammatory, hormonal and nutritional profile significant differences among groups was observed. The groups that received diets with the reduction of the total CH (32% and 35% ) showed improvements in the biochemical profile, specially in the total cholesterol, LDL-c and uric acid, as well as the hormonal profile, in the levels of adiponectin (p< 0,05) . The levels of PCR and TNF-a, only the groups that had the linseed, showed a reduction (p< 0,05). For the triglycerides levels, only the group with the addition of linseed and 32% of total CH showed a decrease. It was observed with 32% of CH and the addition of food lignans constitute a nutritional relevant strategy for the primary prevention of metabolic risk factors and control of subclinical inflammation, contributing to the reduction of the associated morbi-mortality. (AU) | |