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| Author(s): |
Ana Paula Cremasco Takano
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2011-09-02 |
| Examining board members: |
Maria Luiza Morais Barreto de Chaves;
Patricia Chakur Brum;
Anselmo Sigari Moriscot
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| Advisor: | Maria Luiza Morais Barreto de Chaves |
| Abstract | |
Some studies have shown that Thyroid Hormones (TH) are also able to rapidly modulate the phosphorylation state of protein kinases related to cardiac hypertrophy process by non-genomic actions. In this sense, experimental evidences indicate that AMP-activated protein kinase (AMPK) is an important target in the control of hypertrophic growth, since the activation of this enzyme determines wide variety of physiological effects, including the control of enzymes related to protein synthesis. Thus, the objective of this study was to evaluate the effects of TH on the modulation of AMPK signaling pathway and to check the possible involvement of this kinase in vitro model of hypertrophy induced by TH. The results showed that this hormone rapidly activates AMPK and related proteins to this signaling. Furthermore, pharmacological stimulation of AMPK attenuated cardiomyocyte hypertrophy induced by TH. These data suggest that AMPK may correspond to a possible therapeutic tool in cardiovascular disease. (AU) | |
| FAPESP's process: | 09/09922-2 - Role of AMPK in the cardiac hypertrophy induced by Thyroid Hormone. |
| Grantee: | Ana Paula Cremasco Takano |
| Support Opportunities: | Scholarships in Brazil - Master |