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| Author(s): |
Lilian Cristina Buzzetto
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2012-05-24 |
| Examining board members: |
Luiz Vicente Rizzo;
Eliana Faquim de Lima Mauro;
Dewton de Moraes Vasconcelos
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| Advisor: | Luiz Vicente Rizzo |
| Abstract | |
Common Variable Immunodeficiency (CVID) is is characterized by low immunoglobulins levels with susceptibility to infections. We have analyzed T cell distribution and spontaneous apoptosis in peripheral blood of CVID, as well as gene expression of several molecules involved in apoptosis, including death receptors, ligands, adapters, regulatory and anti-apototic molecules in CD4+ and CD8+ cells of 19 CVID patients and 19 healthy subjects. CVID subjects present decreased frequency of TCD4+ and CD4+ CD45RA+ cells and lower CD4/CD8 ratio than healthy controls. CVID group also presented higher frequency of spontaneous apoptosis in lymphocytes and CD4+ cells. CD4+ showed lower expression of TRAIL-R, BCL-2, FLIPL and FADD; CD8+ cells presented lower expression of TRAIL, FADD, BCL-2, BCL-xL and a augment of FLIP. Results suggest an imbalance in mechanisms controlling cell death of those patients lymphocytes, which might help to elucidate the changes observed in T cell compartment of CVID patients. (AU) | |
| FAPESP's process: | 09/12274-2 - Molecular study of extrinsic pathway of apoptosis induction in patients with Common Variable Immunodeficiency |
| Grantee: | Lilian Cristina Buzzetto |
| Support Opportunities: | Scholarships in Brazil - Master |