Full text
| |
| Author(s): |
Bruna Bizzarro
Total Authors: 1
|
| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2012-06-15 |
| Examining board members: |
Anderson de Sá Nunes;
André Luiz Barbosa Báfica;
João Santana da Silva
|
| Advisor: | Anderson de Sá Nunes |
| Abstract | |
Mosquitoes are the most important vectors of human pathogens, transmitting a wide range of emerging and re-emerging infectious diseases. In this scenario, Aedes aegypti is a relevant mosquito species. In the present study, we have investigated the activities of the salivary gland extract (SGE) of this mosquito vector on the dendritic cell and T lymphocyte biology. Our data reveals that the SGE does not interfere on the differentiation, maturation and function of murine dendritic cells. However, salivary components of these mosquitoes have a direct effect on lymphocytes. The mechanism of action of SGE involved apoptosis of naïve T cells, while memory cells were more resistant to this activity. A molecule with molecular weight above 400 kDa is likely responsible for this effect. .Taken together, the results generated by this work contribute to the understanding of the biological effects of Ae. aegypti saliva on the host and, consequently, its role on the transmission of diseases. (AU) | |
| FAPESP's process: | 09/12247-5 - Effect of Aedes aegypti saliva on the differentiation, maturation and function of dendritic cells |
| Grantee: | Bruna Bizzarro |
| Support Opportunities: | Scholarships in Brazil - Master |