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| Author(s): |
Marianne Orlandini Klein
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2012-04-20 |
| Examining board members: |
Luciano Freitas Felicio;
Maria Martha Bernardi;
Ana Carolina Inhasz Kiss
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| Advisor: | Luciano Freitas Felicio |
| Abstract | |
After giving birth, a mother must both provide subsistence and care for her young. Periaqueductal gray (PAG) is an important area for behavioral selection and a site of opioid action. The functional role of PAG opioid receptors in the expression of maternal and predatory behaviors is not clear. Rats with unilateral guide cannulae implanted in the PAG were separated into two experiments: Experiment 1 where the animals received injectios of m receptor agonist, or k receptor agonist, or morphine sulfate, or vehicle; Experiment 2, where they received m receptor antagonist followed by morphine sulfate, or k receptor antagonist before morphine sulfate, or morphine sulfate, or vehicle. The animals were then tested for maternal behavior vs. predatory hunting. The results suggest that endogenous opioid tone is important for the expression of predatory behavior. The results further raise the possibility that morphine acts at more than one type of opioid receptor simultaneously to inhibit maternal behavior in this context. (AU) | |
| FAPESP's process: | 10/06774-0 - The role of opiod receptors in the behavioral selection during lactation |
| Grantee: | Marianne Orlandini Klein |
| Support Opportunities: | Scholarships in Brazil - Master |