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Subsistence and reproduction: opioidergic modulation of behavioral selection during lactation

Grant number: 13/01610-7
Support type:Regular Research Grants
Duration: September 01, 2014 - August 31, 2015
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Luciano Freitas Felicio
Grantee:Luciano Freitas Felicio
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

After delivery, the mother should use her time searching for food and caring for young. Survival of newborns may depends on optimizing the amount time spend on each of these activities. Endogenous mechanisms allow the expression of select female behaviors such as feeding the puppies or seek for food. Recent studies have shown that the periaqueductal gray (PAG) is an important area of central regulation of these behaviors and also seems to be one of the sites of action of opioids. However, functional importance of each opioid receptor in the PAG on the expression of maternal and predatory behaviors is still unknown. The ¼ opioid receptor is widely distributed in the brain, having significant expression in the PAG. Therefore, the main objective of this work is to investigate the importance of the role of ¼ opioid receptor in the rostral lateral PAG on the behavioral selection of rats during lactation. Adult female rats will be tested for the functional relevance of the ¼ opioid receptor in the behavioral selection during lactation. Groups will be formed randomly by animals that will be treated with ¼ receptor agonist or antagonist followed by receptor agonist or, only ¼ antagonist being tested for maternal versus predatory behavior. (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CEZAR, LUANA CARVALHO; KIRSTEN, THIAGO BERTI; NAVARRETE DA FONSECA, CAIO CESAR; NASCIMENTO DE LIMA, ANA PAULA; BERNARDI, MARIA MARTHA; FELICIO, LUCIANO FREITAS. Zinc as a therapy in a rat model of autism prenatally induced by valproic acid. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 84, n. A, p. 173-180, JUN 8 2018. Web of Science Citations: 6.
OCHOA-AMAYA, JULIETA E.; MARINO, LARISSA P.; TOBARUELA, CARLA N.; NAMAZU, LILIAN B.; CALEFI, ATILIO S.; MARGATHO, RAFAEL; GONCALVES, JR., VAGNER; QUEIROZ-HAZARBASSANOV, NICOLLE; KLEIN, MARIANNE O.; PALERMO-NETO, JOAO; LIGEIRO DE OLIVEIRA, ANA P.; MASSOCO, CRISTINA DE O.; FELICIO, LUCIANO F. Attenuated allergic inflammatory response in the lungs during lactation. Life Sciences, v. 151, p. 281-287, APR 15 2016. Web of Science Citations: 2.
OCHOA-AMAYA, JULIETA E.; HAMASATO, EDUARDO K.; TOBARUELA, CARLA N.; QUEIROZ-HAZARBASSANOV, NICOLLE; ANSELMO FRANCI, JANETE A.; PALERMO-NETO, JOAO; GREIFFO, FLAVIA R.; DE BRITTO, AURILEIA APARECIDA; VIEIRA, RODOLFO PAULA; LIGEIRO DE OLIVEIRA, ANA P.; MASSOCO, CRISTINA DE O.; FELICIO, LUCIANO F. Short-term hyperprolactinemia decreases allergic inflammatory response of the lungs. Life Sciences, v. 142, p. 66-75, DEC 1 2015. Web of Science Citations: 7.
KIRSTEN, THIAGO BERTI; CHAVES-KIRSTEN, GABRIELA P.; BERNARDES, SUENE; SCAVONE, CRISTOFORO; SARKIS, JORGE E.; BERNARDI, MARIA MARTHA; FELICIO, LUCIANO F. Lipopolysaccharide Exposure Induces Maternal Hypozincemia, and Prenatal Zinc Treatment Prevents Autistic-Like Behaviors and Disturbances in the Striatal Dopaminergic and mTOR Systems of Offspring. PLoS One, v. 10, n. 7 JUL 28 2015. Web of Science Citations: 16.
CRUZ, WESLEY SOARES; PEREIRA, LUCAS ASSIS; CEZAR, LUANA CARVALHO; CAMARINI, ROSANA; FELICIO, LUCIANO FREITAS; BERNARDI, MARIA MARTHA; TEODOROV, ELIZABETH. Role of steroid hormones and morphine treatment in the modulation of opioid receptor gene expression in brain structures in the female rat. SPRINGERPLUS, v. 4, JUL 16 2015. Web of Science Citations: 2.
KLEIN, MARIANNE ORLANDINI; CRUZ, ALINE DE MELLO; MACHADO, FRANCIELE CORREA; PICOLO, GISELE; CANTERAS, NEWTON SABINO; FELICIO, LUCIANO FREITAS. Periaqueductal gray mu and kappa opioid receptors determine behavioral selection from maternal to predatory behavior in lactating rats. Behavioural Brain Research, v. 274, p. 62-72, NOV 1 2014. Web of Science Citations: 8.

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