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| Author(s): |
Mário Alves de Siqueira Filho
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2008-12-04 |
| Examining board members: |
Carla Roberta de Oliveira Carvalho;
Eliana Hiromi Akamine;
Edson Aparecido Liberti
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| Advisor: | Carla Roberta de Oliveira Carvalho |
| Abstract | |
Reductions in skeletal muscle mass, increased insulin resistance, and decrements in several hormones serum levels, including DHEA, are features observed in aging. Twelve to fourteen months old rats present specific regulation in the insulin and the IGF-1 intracellular pathway in distinct skeletal muscle fiber composition and show reductions in size and proportion of muscle composed predominantly by fiber type 2. DHEA treatment had no effect in these intracellular pathways but induces reduction in the size of type 1 fiber in the EDL muscle. (AU) | |