Effects of diets with different omega 3 fatty acids content on energy metabolism - modulation of peroxisomes function.

Author(s)

Jarlei Fiamoncini

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2011-04-27

Examining board members

Rui Curi; Carla Roberta de Oliveira Carvalho; Ana Maria Pita Lottenberg; Jacqueline Luz; Mario Jose Abdalla Saad

• Advisor: Rui Curi

Abstract

Saturated fatty acids induce insulin resistance, while omega-3 polyunsaturated fatty acids prevent it. Swiss mice were fed on diets containing fish oil at 4% (NFO) and 40% (HFO) or lard at 4% and 40% for eight weeks. The HFO group showed smaller fat mass and body weight compared to HL. In the groups NFO and HFO, basal insulinemia and glycemia and the area under the curve during glucose tolerance test were lower, compared to HL. Despite no differences on skeletal muscle triacylglycerol content, the HFO group had 60% less triacylglycerols in the liver, compared to NL and HL. The lower oxigen consumption associated to the increase in partial oxidation of palmitic acid and activity of acyl CoA oxidase in the liver of the HFO group, indicate increased peroxisomal oxidation of fatty acids. This process demands the metabolization of more fatty acid molecules, contributing to the decresed fat acumulation and preservation of glucose tolerance. (AU)

• FAPESP's process: 06/00345-4 - Modulation of insulin response in rat soleus muscle by omega-3 polyunsaturated fatty acids: effects on protein phosphorylation, PPAR activity, eicosanoids production and role of caveolae
• Grantee: Jarlei Fiamoncini
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)