Ajustes da atividade simpática periférica promovidos pelo treinamento aeróbio em normotensos e hipertensos: efeitos da remoção seletiva dos barorreceptores arteriais.

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Author(s):	Katia Burgi Total Authors: 1
Document type:	Doctoral Thesis
Press:	São Paulo.
Institution:	Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
Defense date:	2012-03-21
Examining board members:	Lisete Compagno Michelini; Vagner Roberto Antunes; Kátia de Angelis Lobo D'Avila; Maria Tereza Jordão; Silvia Lacchini
Advisor:	Lisete Compagno Michelini
Abstract
In the present study we investigate in spontaneous hypertensive rats (SHR) and their normotensive controls (WKY) the effects of exercise training on sympathetic activity to different territories and the effects of the selective removal of arterial baroreceptors on sympathetic activity. SHR and WKY were subjected to sinoaortic denervation (SAD) or sham surgery (SHAM) and submitted to T (50-60% of maximum capacity, 1 hour / day, 5 days/week) or kept sedentary (S) for 3 months.Our data demonstrated that T-induced changes in peripheral sympathetic innervations are tissue-specific and depend on the experimental strain: reduced sympathetic to the heart and kidneys in WKY and SHR strains, and reduced sympathetic activity to the skeletal muscles in the trained WKY, but increased sympathetic activity in the trained SHR, which showed a simultaneous extensive vascular remodeling after training. Our results also demonstrated that training-induced sympathetic adaptations depend on the integrity of the arterial baroreceptors. (AU)