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| Author(s): |
Renato dos Reis Oliveira
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) |
| Defense date: | 2013-04-08 |
| Examining board members: |
Claudio Sergio Pannuti;
Guilherme Santoro Lopes;
Ester Cerdeira Sabino;
Maria Aparecida Shikanai Yasuda
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| Advisor: | Claudio Sergio Pannuti |
| Abstract | |
Currently, the clinical importance of polyomaviruses, especially the morbidity related to BKV infection in renal transplant patients, is well recognized. Although established abroad, in Brazil there is a lack of information available about the incidence of polyomavirus BK in these patients. The main objective of this study was to determine the incidence of BK polyomavirus in sequential samples of urine and plasma of patients undergoing renal transplantation at the Renal Transplant Unit of HCFMUSP. Other objectives were genotyping of circulating viruses, sequencing of VP1 region of the virus to assess the source of BKV infection from the donor and determine if BKV NCCR gene rearrangements would be associated with progression to viremia. The results showed that the incidence of BKV viruria in kidney transplant recipients was 8.1 cases per 100 receptors/month and, within the positive viruria receptors, the incidence of viremia was 3.5 cases per 100 receptors/month. The distribution of genotypes of BKV among recipients showed a predominance of genotype I, mostly belonging to subgroup Ia. Genotypes III and IV, which are considered rare abroad, were identified. The origin of BKV infection seems not to be exclusively from donor, and may be related to reactivation of BKV from the receptor. There was a predominance of archetypal forms of the NCCR BKV in the blood, suggesting that rearranged forms of the virus are not a mandatory condition for progress to viremia. Other studies including a serological analysis, immunosuppressant schedules and clinical data should be undertaken to sustain such results (AU) | |
| FAPESP's process: | 10/01710-3 - PREVALENCE AND MOLECULAR CHARACTERIZATION OF HUMAN POLYOMAVIRUS - BK AND JC - IN KIDNEY TRANSPLANT RECIPIENTS |
| Grantee: | Renato dos Reis Oliveira |
| Support Opportunities: | Scholarships in Brazil - Doctorate |