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Predictive factors or treatment response in patients with obsessive-compulsive disorder

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Author(s):
Roseli Gedanke Shavitt
Total Authors: 1
Document type: Doctoral Thesis
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD)
Defense date:
Examining board members:
Euripedes Constantino Miguel Filho; Valentim Gentil Filho; Clarice Gorenstein; José Alberto Del Porto; Albina Rodrigues Torres
Advisor: Euripedes Constantino Miguel Filho
Abstract

This study investigated predictive factors of treatment response in Obsessive Compulsive Disorder (OCD). Forty-one adults with OCD received exclusively clomipramine for 14 weeks. OCD symptoms and phenomenology of compulsions were assessed by the Yale-Brown Obsessive Compulsive Scale (YBOCS) and the USP-Harvard Repetitive Behaviors Interview, respectively. Response, in terms of percent decrease of the initial YBOCS score, was rated blind to the investigated factors. By the end of a linear regression model, the presence of sensory phenomena preceding the compulsions and being married/cohabiting were associated with a greater response to clomipramine (AU)