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| Author(s): |
Ana Carolina Bione Kunicki
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) |
| Defense date: | 2012-02-03 |
| Examining board members: |
Koichi Sameshima;
Marcelo Fernandes da Costa;
André Frazão Helene;
Marcelo Bussotti Reyes;
Angela Cristina do Valle
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| Advisor: | Koichi Sameshima |
| Abstract | |
The establishment of long-term memories requires effective communication of the hippocampus to the neocortex. Electrophysiological activities between hippocampus and prefrontal cortex have shown higher theta synchronization during retrieval of aversive memories and lower during extinction learning. While theta activity is more differently related to learning and memory, delta waves have been more discussed in the context of sleep or \"offline\" states. Few studies have investigated delta waves during \"on-line\" states (such as task-relevant situations) and the contribution of these rhythms to memory storage remains unclear. We recorded electrophysiological data to study the contributions of delta and theta waves in cortico-hippocampal system of rats underwent to contextual fear conditioning. Our experiment consisted of environmental pre-exposition, training with electrical footshocks, and recent/remote memory tests. Two groups of rats were tested one or eighteen days post training for recent or remote memory, respectively. Local field potential time series of two behavioral states were sampled: active exploration and freezing. The results showed that theta and delta rhythms play an important role in behavioral responses and memory processing. They are related to fear recall and their contribution depend on the recent or remote memory. Additionally, using an order parameter we show that theta contribution is strongly pronounced in active exploration, decreasing during freezing. In the latter, the rats presented pronounced delta waves in freezing. Moreover, a behavioral-dependent causality measure showed an increase of theta influence in delta rhythms, resulting in a theta slowing in aversive memory retrieval. Finally, we show an increased synchrony between hippocampus and prefrontal cortex during recall of recent memory, but a decreased synchrony in remote memory. We proposed that synchronized activity may facilitate the communication of information and once the memories are established in the neocortex, the synchronization decreases, and recalling them becomes more independent of the hippocampus. We proposed that delta-theta oscillations of the hippocampus over neocortical areas reflect information processing during aversive memory retrieval (AU) | |
| FAPESP's process: | 07/08426-6 - Cortico-hippocampal system dynamics during contextual fear conditioning |
| Grantee: | Ana Carolina Bione Kunicki |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |