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| Author(s): |
Caroline Cristiano Real
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2013-05-20 |
| Examining board members: |
Luiz Roberto Giorgetti de Britto;
Ricardo Cardoso Cassilhas;
Rosana de Lima Pagano;
Ana Carolina Thomaz Takakura;
Andréa da Silva Torrão
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| Advisor: | Luiz Roberto Giorgetti de Britto |
| Abstract | |
Exercise is known to produce beneficial effects to the nervous system, The objective of this project was to investigate the histological and behavioral changes promoted by physical exercise in the PD model induced by 6-hydroxydopamine (6-OHDA) in rats, and the role of BDNF in the changes. The study was divided into two stages, aimed at evaluating the neuroprotective and the preventive effects of exercise. To analyze the effects of BDNF we used intrastriatal injections of a BDNF receptor blocker (K252a). The exercise protocol consisted of treadmill exercise (3x/week, 40 minutes). We carried out behavioral tests and histological analysis of the substantia nigra pars compacta and the striatum. The results showed, in general, that exercise is effective in improving the dopaminergic system and able to improve the behavior of rats injected with 6-OHDA. We also demonstrated that the positive effects of intermittent exercise appear to involve the BDNF-TrkB system, suggesting this as an important preventive and neuroprotective system in PD. (AU) | |