Effects of physical exercise on leptina signaling in the hypothalamus of rats: the role of neuronal S1PR1

Author(s)

Vagner Ramon Rodrigues Silva

• Document type: Master's Dissertation
• Press: Campinas, SP.
• Institution: Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas
• Defense date: 2013-11-11

Examining board members

Eduardo Rochete Ropelle; Bruno de Melo Carvalho; Marciane Milanski

• Advisor: Eduardo Rochete Ropelle

Abstract

The food intake and energy expenditure are closely regulated by specific neurons in the hypothalamus. During the last two decades, the location of the leptin receptor in hypothalamic nuclei as well as the description of the route of transmission Intracellular triggered by this hormone in hypothalamic neurons, were crucial to the understanding of the control of food intake and energy expenditure.Increasingly, eating disorders, diseases associated with obesity are related to signal transmission malfunction of leptin in the hypothalamus. The subclinical inflammatory process frequently observed in experimental models of obesity are directly associated with distinct mechanisms of leptin resistance in the hypothalamus and result in increased food intake and body weight gain. Furthermore, studies have shown that physical exercise can increase the sensitivity of leptin in the hypothalamus of obese animals, through of antiinflammatory cytokines, however, these mechanisms remain only partially understood. Recently, the protein S1PR1 (sphingosine-1-phosphate receptor-1) was described as a molecule with high ability to exert potent synergistic effects on the signaling pathway of leptin, supporting the activation of Jak2/STAT3 in some cell lines. Thus, this project aims to investigate the effects of exercise on the activity of SIPR1 and leptin sensitivity in hypothalamus of obese rodents. We believe that the completion of this project will contribute to characterize the involvement of S1PR1 in leptin signaling in the hypothalamus, and to determine the effects of exercise on the activity of neuronal S1PR1 (AU)

• FAPESP's process: 11/13828-1 - Effects of physical exercise on leptin signaling in the hypothalamus of rats: The role of neuronal S1PR1.
• Grantee: Vagner Ramon Rodrigues Silva
• Support Opportunities: Scholarships in Brazil - Master