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| Author(s): |
Natalia Ribeiro
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2013-09-23 |
| Examining board members: |
Vagner Roberto Antunes;
Ruy Ribeiro de Campos Junior;
Thiago dos Santos Moreira
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| Advisor: | Vagner Roberto Antunes |
| Abstract | |
Diverse studies demonstrated that osmorality increase is able of causing simpatoexcitação and increase in arterial pressure, with paraventricular hypothalamic nucleus (PVN) involved in this response. Studies showed an role of VP modulating the activity of neurons in the PVN involved in the control of sympathetic activity. In this way, the aim of this study was to investigate the role of the vasopressina, through it\'s action in the PVN, over the alterations in the sympathetic activity induced by hiperosmolality.The results showed that bilateral microinjection of VP into the PVN is able of increase significatively the lumbar sympathetic nerve activity. Moreover, the bilateral block of the V1a receptors into PVN of animals subjected to osmotic stimulus showed a decrease in sympathetic activity not observed in normohydrated animals. Overall, the results allow to assert that the centrally released VP plays an important role in the development of the simpatoexcitation raised by increased osmolarity, through an action on the PVN neurons. (AU) | |
| FAPESP's process: | 11/04778-0 - Role of vasopressin in the paraventricular nucleus of hypothalamus on hyperosmolality-induced sympathoexcitation |
| Grantee: | Natália Ribeiro |
| Support Opportunities: | Scholarships in Brazil - Master |