Pharmacological evaluation of hybrid compounds anti-inflammatory and analgesic nonsteroidal donors of hydrogen sulfide in arthritis and chronic pain.

Author(s)

Filiphe de Paula Nunes Mesquita

• Document type: Master's Dissertation
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2013-12-06

Examining board members

Soraia Kátia Pereira Costa; Stephen Hyslop; Rodrigo Alvaro Brandão Lopes Martins

• Advisor: Soraia Kátia Pereira Costa

Abstract

Despite recent knowledge of the anti-inflammatory and anti-nociceptive role of H2S in the carrageenin-induced arthritis (CGN) in rats, the mechanisms involved are not yet known. Nor is it known whether hybrid compounds antiinflammatory drugs (NSAIDs) H2S donors have additional pharmacological advantages when compared to classical H2S donors. Although H2S exert an anti-nociceptive effect in models of inflammation and acute pain, little is known about the role of this gas in chronic pain . In this study we investigated the protective mechanisms of H2S in the model of synovitis and chronic pain . It was found that the K+ATP channel, L type Ca2+ channel or TRPV1 receptors are not involved in the protective mechanism of H2S in synovitis , decreased IL-1b and increased IL-10 and there was no difference in the participation of oxidant enzymes GPx and GR . Still, the acute treatment with H2S donor did not reverse the discomfort of the Rota Rod test and thermal allodynia. (AU)

• FAPESP's process: 11/16645-5 - PHARMACOLOGICAL EVALUATION OF HYBRID NON STEROID COMPOUNDS DONORS OF HYDROGEN SULFIDE IN ARTRITIS (SYNOVITIS) AND CHRONIC PAIN
• Grantee: Filiphe de Paula Nunes Mesquita
• Support Opportunities: Scholarships in Brazil - Master