Full text
| |
| Author(s): |
Rosélia dos Santos Damasceno
Total Authors: 1
|
| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2014-03-20 |
| Examining board members: |
Thiago dos Santos Moreira;
Maria Camila Almeida;
Luciane Helena Gargaglioni Batalhão;
Débora Simões de Almeida Colombari;
Sara Joyce Shammah Lagnado
|
| Advisor: | Thiago dos Santos Moreira |
| Abstract | |
Here we evaluated the involvement of Kölliker-Fuse region (KF) and lateral parabrachial nucleus (LPBN) in the cardiorespiratory responses elicited by chemoreceptor activation in conscious rats. Bilateral injection of muscimol (200 pmol/100 nl) into the KF decreased resting ventilation (978 ± 100, vs. saline: 1436 ± 155 ml/kg/min). Muscimol injection into the KF reduced the increase in ventilation (1827 ± 61, vs. saline: 3179 ± 325 ml/kg/min) produced by hypoxia (8% O2 - 10 min) or hypercapnia (7% CO2 - 10 min) (1488 ± 277, vs. saline: 3539 ± 374 ml/kg/min). The injection of muscimol into the LPBN increased resting MAP (D =119 ± 2, vs. saline: 104 ± 2 mmHg). Muscimol into the LPBN did not change the increase in ventilation elicited by hypoxia or hypercapnia in unrestrained rats. The results of the present study suggest that KF region, but not LPBN, have mechanisms to control the ventilation in resting, hypoxic or hypercapnic conditions in conscious rats. (AU) | |
| FAPESP's process: | 10/15692-7 - Involvement of the Kolliker-Fuse in cardiorespiratory control during activation of central and peripheral chemoreceptors |
| Grantee: | Rosélia dos Santos Damasceno |
| Support Opportunities: | Scholarships in Brazil - Doctorate |