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Pontine mechanisms involved in cardiorespiratory control during central or peripheral chemoreceptors activation

Abstract

Pontine nuclei involved in autonomic and respiratory control are the noradrenergic A5 region, intertrigeminal region, parabrachial complex and the Kolliker-Fuse (A7 noradrenergic region). The noradrenergic A5 region is an important region located in the ventrolateral pons that receives several afferents from brainstem neurons involved in cardiorespiratory control. Kolliker-Fuse/A7 noradrenergic region project massively to brainstem respiratoy columm. Both regions are well involved in autonomic regulation like water and sodium intake, gastrointestinal control and cardiorespiratory regulation. In addition, both regions are also involved in the Hering-Breuer reflex and peripheral chemoreflex. Preliminary experiments from our laboratory have shown that A5 or A7 regions have extensively projections to the chemosensitive neurons located in the retrotrapezoid nucleus (RTN). Based on these informations, the aims of the present project are: 1) to evaluate the role of the A5 and A7 regions in cardiorespiratory control at baseline and during central or peripheral chemoreflex activation; 2) to evaluate the role of A5 or A7 noradrenergic neurons in cardiorespiratory control at baseline and during central or peripheral chemoreflex activation and 3) to investigate a possible anatomic pathway between the A5 or A7 noradrenergic neurons and the RTN chemosensitive neurons. (AU)

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOBRINHO, CLEYTON R.; WENKER, IAN C.; POSS, ERIN M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; MULKEY, DANIEL K.. Purinergic signalling contributes to chemoreception in the retrotrapezoid nucleus but not the nucleus of the solitary tract or medullary raphe. JOURNAL OF PHYSIOLOGY-LONDON, v. 592, n. 6, p. 1309-1323, . (11/13462-7, 10/09776-3, 10/19336-0)
DAMASCENO, ROSELIA S.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Respiratory and sympathetic chemoreflex regulation by Kolliker-Fuse neurons in rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 467, n. 2, p. 231-239, . (10/15692-7, 10/09776-3, 10/19336-0)
TOTOLA, L. T.; ALVES, T. B.; TAKAKURA, A. C.; FERREIRA-NETO, H. C.; ANTUNES, V. R.; MENANI, J. V.; COLOMBARI, E.; MOREIRA, T. S.. COMMISSURAL NUCLEUS OF THE SOLITARY TRACT REGULATES THE ANTIHYPERTENSIVE EFFECTS ELICITED BY MOXONIDINE. Neuroscience, v. 250, p. 80-91, . (11/11934-9, 09/54888-7, 10/09776-3, 10/19336-0, 11/50770-1)
TAXINI, C. L.; TAKAKURA, A. C.; GARGAGLIONI, L. H.; MOREIRA, T. S.. CONTROL OF THE CENTRAL CHEMOREFLEX BY A5 NORADRENERGIC NEURONS IN RATS. Neuroscience, v. 199, p. 177-186, . (10/09776-3, 10/15501-7, 10/19336-0)
TAKAKURA, ANA C.; MOREIRA, THIAGO S.; DE PAULA, PATRICIA M.; MENANI, JOSE V.; COLOMBARI, EDUARDO. Control of breathing and blood pressure by parafacial neurons in conscious rats. Experimental Physiology, v. 98, n. 1, p. 304-315, . (09/54888-7, 10/09776-3, 10/19336-0)
BARNA, B. F.; TAKAKURA, A. C.; MOREIRA, T. S.. PONTOMEDULLARY AND HYPOTHALAMIC DISTRIBUTION OF FOS-LIKE IMMUNOREACTIVE NEURONS AFTER ACUTE EXERCISE IN RATS. Neuroscience, v. 212, p. 120-130, . (10/09776-3, 10/19336-0)
WENKER, IAN C.; SOBRINHO, CLEYTON R.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; MULKEY, DANIEL K.. Regulation of ventral surface CO2/H+-sensitive neurons by purinergic signalling. JOURNAL OF PHYSIOLOGY-LONDON, v. 590, n. 9, p. 2137-2150, . (11/13462-7, 10/09776-3, 10/19336-0)
WENKER, IAN C.; SOBRINHO, CLEYTON R.; TAKAKURA, ANA C.; MULKEY, DANIEL K.; MOREIRA, THIAGO S.. P2Y1 Receptors Expressed by C1 Neurons Determine Peripheral Chemoreceptor Modulation of Breathing, Sympathetic Activity, and Blood Pressure. Hypertension, v. 62, n. 2, p. 263-273, . (11/13462-7, 10/09776-3, 10/19336-0)

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