Involvement of the Kolliker-Fuse in cardiorespiratory control during activation of...
Grant number: | 10/19336-0 |
Support type: | Regular Research Grants |
Duration: | July 01, 2011 - June 30, 2013 |
Field of knowledge: | Biological Sciences - Physiology |
Principal Investigator: | Thiago dos Santos Moreira |
Grantee: | Thiago dos Santos Moreira |
Home Institution: | Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract
Pontine nuclei involved in autonomic and respiratory control are the noradrenergic A5 region, intertrigeminal region, parabrachial complex and the Kolliker-Fuse (A7 noradrenergic region). The noradrenergic A5 region is an important region located in the ventrolateral pons that receives several afferents from brainstem neurons involved in cardiorespiratory control. Kolliker-Fuse/A7 noradrenergic region project massively to brainstem respiratoy columm. Both regions are well involved in autonomic regulation like water and sodium intake, gastrointestinal control and cardiorespiratory regulation. In addition, both regions are also involved in the Hering-Breuer reflex and peripheral chemoreflex. Preliminary experiments from our laboratory have shown that A5 or A7 regions have extensively projections to the chemosensitive neurons located in the retrotrapezoid nucleus (RTN). Based on these informations, the aims of the present project are: 1) to evaluate the role of the A5 and A7 regions in cardiorespiratory control at baseline and during central or peripheral chemoreflex activation; 2) to evaluate the role of A5 or A7 noradrenergic neurons in cardiorespiratory control at baseline and during central or peripheral chemoreflex activation and 3) to investigate a possible anatomic pathway between the A5 or A7 noradrenergic neurons and the RTN chemosensitive neurons. (AU)