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| Author(s): |
Henrique Borges da Silva
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2014-04-11 |
| Examining board members: |
Maria Regina D\'Imperio Lima;
Marcelo Urbano Ferreira;
Gustavo Batista de Menezes;
Mauricio Martins Rodrigues;
José Ronnie Carvalho de Vasconcelos
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| Advisor: | Maria Regina D\'Imperio Lima |
| Abstract | |
The immune system is considered crucial for the protection against Plasmodium infection. Among the mechanisms involved in the control of blood-stage parasites, the ones mediated by antibodies are widely recognized. However, other mechanisms of immune system can also exert fundamental roles, being less studied. This work had the objective of describing some of the effector mechanisms important in the immune response to blood-stage experimental malaria. This work was subdivided in two main branches: a) to verify the relation between the IFN-g-induced priming and the protective immunity to the parasite during the chronic phase of blood-stage infection; and b) to describe separately the role of dendritic cells and splenic macrophages as phagocytic cells during acute Plasmodium chabaudi infection, and the subsequent role of these cells in the immune responses during this period. The results obtained in this project may contribute for the comprehension of the mechanisms involved in the immunity against malaria. (AU) | |
| FAPESP's process: | 09/08559-1 - Characterization of effector mechanisms of innate and acquired immunity in chronic malaria model of CD28KO mice infected with Plasmodium chabaudi AS |
| Grantee: | Henrique Borges da Silva |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |