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RECOMBINANT PROTEIN, METHOD FOR CONSTRUCTING THE SAME AND USE FOR TREATING DISORDERS ASSOCIATED WITH UNDESIRABLE CELL PROLIFERATION

Document type:Patente
Inventor(s): André Lopes Carvalho; Matias Eliseo Melendez
Applicant: Fundação Pio XII (FP)
Deposit date: December 2015, 10
INPI register:
PCT/BR2015/050244
IPC: A61P 35/00 C12N 15/66 C12N 15/62 C07K 19/00 A61K 35/18
Abstract

(EN) This invention describes a method for contructing a recombinant protein by fusion with the FOLDON domain, the protein being transfected and expressed in a non-viral vector. The recombinant protein is capable of inducing cell apoptosis by interaction with the DR4 and DR5 membrane receptors, and is used for the treatment of disorders associated with undesirable cell proliferation.


FAPESP's process: 12/14837-7 - Evaluation of the expression profile of microRNAs as diagnostic markers for cervical metastasis in patients with head and neck squamous cell carcinoma
Grantee:André Lopes Carvalho
Principal Investigator:André Lopes Carvalho
Institution: Fundação Pio XII (FP). Hospital do Câncer de Barretos
Support Opportunities: Regular Research Grants