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RECOMBINANT PROTEIN, METHOD FOR CONSTRUCTING THE SAME AND USE FOR TREATING DISORDERS ASSOCIATED WITH UNDESIRABLE CELL PROLIFERATION
| Document type: | Patente |
| Inventor(s): | André Lopes Carvalho; Matias Eliseo Melendez |
| Applicant: | Fundação Pio XII (FP) |
| Deposit date: | December 2015, 10 |
| INPI register: | |
| IPC: | A61P 35/00 C12N 15/66 C12N 15/62 C07K 19/00 A61K 35/18 |
Abstract
(EN) This invention describes a method for contructing a recombinant protein by fusion with the FOLDON domain, the protein being transfected and expressed in a non-viral vector. The recombinant protein is capable of inducing cell apoptosis by interaction with the DR4 and DR5 membrane receptors, and is used for the treatment of disorders associated with undesirable cell proliferation.
| FAPESP's process: | 12/14837-7 - Evaluation of the expression profile of microRNAs as diagnostic markers for cervical metastasis in patients with head and neck squamous cell carcinoma |
| Grantee: | André Lopes Carvalho |
| Principal Investigator: | André Lopes Carvalho |
| Institution: | Fundação Pio XII (FP). Hospital do Câncer de Barretos |
| Support Opportunities: | Regular Research Grants |