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Evaluation of the expression profile of microRNAs as diagnostic markers for cervical metastasis in patients with head and neck squamous cell carcinoma

Grant number: 12/14837-7
Support type:Regular Research Grants
Duration: November 01, 2012 - October 31, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:André Lopes Carvalho
Grantee:André Lopes Carvalho
Home Institution: Hospital do Câncer de Barretos. Fundação Pio XII (FP). Barretos , SP, Brazil
Assoc. researchers:Andre Luiz Vettore de Oliveira ; Cristovam Scapulatempo Neto

Abstract

Head and Neck Squamous Cell Carcinoma (HNSCC) is characterized by lesions that often have local invasion and lymph node metastasis. The development of locoregional recurrence is the main reason for treatment failure and the presence or absence of metastatic disease in cervical lymph nodes is the most important determinant in the therapy choice and in the determination of the patient prognosis. Thus, the correct staging of regional lymph node metastases is of paramount importance to the success of locoregional control of disease, response to treatment and thus influences the overall survival of these patients.Recent studies have shown that microRNAs are involved in regulating the process of tumor metastasis, acting in various signaling pathways involved in this process. Thus, this study aims to identify microRNAs that can be used as molecular markers associated with cervical metastasis in patients with HNSCC, enabling the development of a more sensitive, specific and rapid diagnosis of these metastases and a design more appropriate therapy to treat these patients. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGUES-JUNIOR, DORIVAL MENDES; BIASSI, THAIS PRISCILA; DE ALBUQUERQUE, GABRIELA ESTRELA; CARLIN, VIVIANE; BURI, MARCUS VINICIUS; MACHADO-JUNIOR, JOEL; VETTORE, ANDRE LUIZ. Downregulation of DCC sensitizes multiple myeloma cells to bortezomib treatment. MOLECULAR MEDICINE REPORTS, v. 19, n. 6, p. 5023-5029, JUN 2019. Web of Science Citations: 0.
RODRIGUES-JUNIOR, DORIVAL MENDES; BIASSI, THAIS PRISCILA; CARLIN, VIVIANE; BURI, MARCUS VINICIUS; TORRECILHAS, ANA CLAUDIA; BORTOLUCI, KARINA RAMALHO; VETTORE, ANDRE LUIZ. OIP5 Expression Sensitize Glioblastoma Cells to Lomustine Treatment. JOURNAL OF MOLECULAR NEUROSCIENCE, v. 66, n. 3, p. 383-389, NOV 2018. Web of Science Citations: 1.
MAIA, DANIELLE; DE CARVALHO, ANA CAROLINA; HORST, MARIA ADERUZA; CARVALHO, ANDRE LOPES; SCAPULATEMPO-NETO, CRISTOVAM; VETTORE, ANDRE LUIZ. Expression of miR-296-5p as predictive marker for radiotherapy resistance in early-stage laryngeal carcinoma. JOURNAL OF TRANSLATIONAL MEDICINE, v. 13, AUG 12 2015. Web of Science Citations: 26.
DE CARVALHO, ANA CAROLINA; SCAPULATEMPO-NETO, CRISTOVAM; CAMPELO MAIA, DANIELLE CALHEIROS; EVANGELISTA, ADRIANE FEIJO; MORINI, MARIANA ANDOZIA; CARVALHO, ANDRE LOPES; VETTORE, ANDRE LUIZ. Accuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell carcinoma. BMC MEDICINE, v. 13, MAY 9 2015. Web of Science Citations: 13.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Filed patent(s) as a result of this research project

PROTEÍNA RECOMBINANTE; PROCESSO DE CONSTRUÇÃO DA MESMA E O USO PARA O TRATAMENTO DE DISTÚRBIOS RELACIONADOS COM A PROLIFERAÇÃO CELULAR INDESEJADA BR1020140311858 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Fundação Pio XII (FP) . André Lopes Carvalho; Matias Eliseo Melendez - December 2014, 12

MÉTODO DE DETECÇÃO DE CÉLULAS METASTÁTICAS EM LINFONODOS DE PACIENTES COM CARCINOMA EPIDERMÓIDE DE CABEÇA E PESCOÇO E USO DE MICRORNAS COMO MARCADORES BR1020150033109 - Fundação Pio XII (FP) ; Universidade Federal de São Paulo (UNIFESP) . André Lopes Carvalho; Ana Carolina de Carvalho Peters; Cristovam Scapulatempo Neto; André Luiz Vettore - February 2015, 13

RECOMBINANT PROTEIN, METHOD FOR CONSTRUCTING THE SAME AND USE FOR TREATING DISORDERS ASSOCIATED WITH UNDESIRABLE CELL PROLIFERATION PCT/BR2015/050244 - Fundação Pio XII (FP) . André Lopes Carvalho; Matias Eliseo Melendez - December 2015, 10