IN VITRO METHOD FOR PREDICTING A RISK OF POST-CHIKUNGUNYA CHRONIC INFLAMMATORY JOINT DISEASE

Office	WIPO
Document type:	Patent
Inventor(s):	Carolina Dos Santos Lazari; Marina Farrel Cortes; Erika Regina Manuli; Glaucia Paranhos Baccala; Ester Cerdeira Sabino; Mariana Severo Ramundo; Felipe Ten Caten

Applicant:	Biomérieux; Universidade de São Paulo (USP).
Year:	2023
Application Number:	PCT/EP2023/054212
IPC:	C12Q 1/6883

Abstract

The invention relates to the field of in vitro diagnosis or prognosis. The invention provides in vitro methods and kit for predicting the risk of developing Post-Chikungunya Chronic Inflammatory Joint Disease (pCHIKV-CIJD) in a subject. The method comprises a step of evaluating the expression of one or more biomarkers in a biological sample obtained from said subject, for example a blood sample, wherein said one or more biomarkers are selected among specific long non-coding RNAs, and wherein a higher expression than control expression value indicates a risk of developing pCHIKV-CIJD.

FAPESP's process:	16/20597-0 - A translational study for the identification, characterization and validation of severity biomarkers in arboviral infections
Grantee:	Ester Cerdeira Sabino
Principal Investigator:	Ester Cerdeira Sabino
Institution:	Universidade de São Paulo (USP). Faculdade de Medicina (FM)
Support Opportunities:	Research Grants - Research Partnership for Technological Innovation - PITE

Short URL