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METHODS OF PHSYCOCHEMICAL-GUIDED PEPTIDE DESIGN AND NOVEL PEPTIDES DERIVED THEREFROM
| Office | USPTO |
| Document type: | Patent |
| Inventor(s): | Timothy Kuan Lu-Ta; Cesar De La Fuente Nunez; Vani Xavier De Oliveira Junior; Marcelo Der Torossian Torres |
| Applicant: | Fundação Universidade Federal do ABC (UFABC); Massachusetts Institute of Technology (MIT) |
| Year: | 2018 |
| Application Number: | US 62/734,298 |
| IPC: | A61K 38/10 A61P 31/00 C07K 14/00 |
Abstract
Described herein are methods pf physicochemical-guided peptide design that utilize specific functional determinants to a protein's property of the interest. Also described herein are novel synthetic peptide antibiotics that have increased potentcy and/or decreased toxicidity relative to the template peptide from which they were derived, and methods of use thereof in trating microbial infections
| FAPESP's process: | 17/03046-2 - Biologically active peptides against pathogenic microorganisms and cancer cells |
| Grantee: | Vani Xavier de Oliveira Junior |
| Principal Investigator: | Vani Xavier de Oliveira Junior |
| Institution: | Universidade Federal do ABC (UFABC). Centro de Ciências Naturais e Humanas (CCNH) |
| Support Opportunities: | Regular Research Grants |