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IMMUNOGENICAL COMPLEX FORMED BY VACCINAL ANTIGENS ENCAPSULATED BY NANOSTRUCTURED MESOPOROUS SILICA

OfficeUSPTO
Document type:Patent
Inventor(s): Ogari De Castro Pacheco; Osvaldo Augusto Brazil Esteves Sant'Anna; Lucildes Pita Mercuri; Jivaldo Do Rosário Matos; Marcia Carvalho De Abreu Fantini
Applicant:Cristália Produtos Químicos Farmacêuticos Ltda
Year: 2006
Application Number:US 12/066,489
IPC: A61K 9/50 A61P 37/02
Abstract

The present invention relates to a product named "immunogenical complex", which comprises an adjuvant characterized by solid particles of highly ordinated nanostructured mesoporous silica, preferably, SBA-15 Silica, and vaccinal antigens of several natures, encapsulated in the referred to adjuvants. The immunogenical complex of the present invention allows the presentation of the antigens that compose it to lymphocytes, in a safe, gradual and extended way, which leads to a more efficient immunological memory, increases the immunogenicity of the antigen and improves the production of antibodies. This ensures an efficient immunological protection with fewer amounts of antigens and/or less repetitions of vaccinal doses. In addition, the characteristics of the immunogenical complex of the present invention promotes effective immunity induction, homogeneous in "god and bad respondent" individuals.


Grantee:Luciana Vieira Carvalho
Principal Investigator:Osvaldo Augusto Brazil Esteves Sant'Anna
Institution: Secretaria da Saúde (São Paulo - Estado). Instituto Butantan
Support Opportunities: Scholarships in Brazil - Master