4-ANILINEQUINAZOLINES WITH ADENOSINE_KIASE PRPERTIES

Office	CNIPA
Document type:	Patent
Inventor(s):	Kleber Gomes Franchini; Mario Jose Abdalla Saad; Roberto Rittner Neto; Rodrigo Miguel Marin; Aparecida Silvana Rocco

Applicant:	Universidade Estadual de Campinas Unicamp
Year:	2004
Application Number:	CN 200480042739
IPC:	A61K 31/517 C07D 239/94

Abstract

The present invention describes adenosine-kinase inhibitor compounds. We provide a method of protecting tissues and organs affected by ischemia, such as the heart, brain and kidneys, as well as treating cardiac insufficiency, myocardial infarction, arrhythmia, high arterial pressure, atherosclerosis, angioplasty methods for coronary artery restenosis, chronic renal insufficiency, cerebrovascular accidents, and chronic inflammatory diseases (eg, rheumatoid arthritis). We also provide adenosine-kinase inhibitory effects of compounds derived from quinazolines, which were previously recognized as reversible inhibitors of tyrosine-kinases from the epidermal growth factor receptor (EGFR) family.

FAPESP's process:	01/11698-1 - Signaling Mechanisms Induced by Mechanical Overload: Role in Myocardial Hypertrophy and Remodeling
Grantee:	Kleber Gomes Franchini
Principal Investigator:	Kleber Gomes Franchini
Institution:	Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas (FCM)
Support Opportunities:	Research Projects - Thematic Grants

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