CV Lattes
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Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Associate professor at IQSC-USP leading the Chemical Discovery Group (CDG). He got his bachelor in Pharmacy Biochemistry with PhD. in Chemistry from the Federal University of Minas Gerais. He has two post-docs: University of New Mexico (USA) and University of Duisburg-Essen (Germany). He has experience in drug discovery applying cheminformatics, medicinal chemistry and cell-based assays in cancer. (Source: Lattes Curriculum)
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Cysteine cathepsins B, L, and S are macromolecules associated with the progression of various types of cancer. The research group has been dedicated to studying cysteine protease inhibitors, with over 500 dipeptidyl nitriles and derivatives planned and synthesized in 9 years of activity. Some compounds show high affinity and potency against cysteine cathepsins B, L, and S, commonly involv…
The drug discovery process is time-consuming and often leads to dead ends. This is especially true for the study of bioactive substance for cancer diseases, in which new therapeutic approaches are eagerly needed. Cathepsin inhibitors are described in the literature as potential novel antineoplastic compounds, inhibiting the migration and invasion of cancer cells. In this work, it is devis…
Many of the discoveries from the rapidly expanding genomic sciences are not effectively utilized in medicine, agriculture and industry. This is partly because of the disconnection between scientists in different disciplines, and because much of the translational research done in both industry and academia is patent-protected and not published in a timely manner. This INCT proposal address…
(Only some records are available in English at this moment)
Pancreatic Cancer has high mortality rate according to the Brazilian National Cancer Institute (INCA). Gemcitabine is a drug usually applied in this case, but it has many limitations. Therefore, novel therapeutic alternatives are needed. Cysteine proteases present enormous physiopathological relevance, being overexpressed in many Cancer types, including the pancreatic adenocarcinoma. Amon…
Pancreatic and liver cancers, characterized by elevated mortality rates, pose significant challenges in chemotherapy, leading to the exploration of novel therapeutic approaches. Cathepsins B, L, and S have been identified as key players in the neoplastic process, offering potential targets for covalent reversible and irreversible inhibitors using dipeptidyl nitrile derivatives. Dipeptidyl…
Cysteine protease inhibitors have been described as cytostatic agents working as inhibitors of metastasis in many neoplasias, among them in pancreatic cancer cell lines. These cells overexpress cysteine proteases. In this Project, in vitro assays using the pancreatic cell line (MIA PaCa-2) and Balb/C 3T3 clone A31 mouse fibroblasts will be used to determine the selectivity profile for a s…
The research of novel bioactive substances is directly linked to its mechanism of action. In vitro studies are of great importance to determine the mode of action and cell-based assays are cornerstone to this outcome. Here the analysis of cysteine protease inhibition by means of a fluorescent chemical probe is going to be proposed to observe whether there will be fluorescence reduction. T…
Cysteine cathepsin B and L (CTSB and CTSL) inhibitors present antineoplastic activity, as described in many reports in the literature. There is mounting evidence that these compounds could inhibit cancer progression and metastasis. Compounds 709 and 1031 are inhibitors of cysteine cathepsins, being cytotoxic to the pancreatic (MIA PaCa-2) cancer cells. Here, the mechanism of action for th…
| 1 / 1 | Ongoing grants |
| 6 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 3 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 12 / 10 | All research grants and scholarships |
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