CV Lattes
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Sociedade Regional de Ensino e Saúde S/S Ltda (SRES). Faculdade São Leopoldo Mandic (SLMANDIC). Centro de Pesquisas Odontológicas São Leopoldo Mandic (Institutional affiliation for the last research proposal) Birthplace: Brazil
Dr. Clemente-Napimoga is graduated in dentistry (2002) and completed her master (2004) and PhD degree (2006) in Oral Physiology at Piracicaba Dental School, University of Campinas, Brazil. Dr. Clemente-Napimoga has been working in the field of orofacial pain conditions with financial support from different agencies from Brazil. Since 2018, the Brazilian funding agency CNPq has recognited her important scientific contribution awarding with a Scientific Productivity Fellowship. Currently, Dr. Clemente-Napimoga is a Professor of Physiology Area, Dental and Medical School, Faculdade São Leopoldo Mandic (Brazil). Her research interests are in the fields of orofacial pain conditions and potential therapies for that. Her laboratory is currently investigating the interface of neuroimmune interface of inflammatory pain condition in the temporomandibular joint and new pharmacological interventions to treat TMJ pain. (Source: Lattes Curriculum)
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This project proposes the use of two drug release systems, the polymer nanoparticles and the microneedles patch, for the development and applicability of two formulations with immunomodulatory and neuroprotective potential. Epoxy-eicosatrienoic acid (EET) is a product of arachidonic acid metabolism catalyzed by cytochrome P450 epoxygenases. These small molecules are lipid mediators, which…
Rheumatoid arthritis (RA) is an autoimmune polyarthritis resulting in a systemic condition of chronic inflammation affecting synovial joints and the temporomandibular joint (TMJ), the main complaint of pain patients. It was demonstrated that peripheral injuries resulted from albumin-induced arthritis in the TMJ of rats promote the activation of microglial cells in the trigeminal subnucleu…
Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease that results in the destruction of cartilage and bone including the temporomandibular joint (TMJ). The inflammatory process started in the synovial membrane and due to its progressive characteristics extends to the articular superficies leading to deformation and articular destruction of the bone and cartilages. The T…
Epoxy-eicosatrienoic acids (EETs) are products of arachidonic acid metabolism catalyzed by epoxygenases of cytochrome P450. EETs have important biological activity, including anti-inflammatory, neuroprotective and neuromodulatory effects. EETs have a very short half-life since they are rapidly hydrolyzed by the enzyme soluble epoxy hydrolase (sEH), reducing their bioavailability. Thus, st…
Epoxy-eicosatrienoic acids (EETs) are molecules of intracellular lipid signaling that have important biological activities, such as vasodilation, anti-inflammation and analgesic effects. However, EETs have a very short half-life since they are rapidly hydrolyzed by the soluble epoxy hydrolase enzyme (sEH), reducing their bioavailability. Thus, the inhibitors of the sEH enzyme arouse great…
The Rheumatoid Arthritis (RA) is a polyarthritis autoimmune that results in a chronic systemic inflammation affecting synovial joints such as the Temporomandibular Joint (TMJ) and being the pain the main complaint of patients. A previous study (FAPESP # 2011/18951-6) demonstrated that the RA induced experimentally in rat's TMJ causes a persistent hypernociception linked to the formation a…
Tramadol hydrochloride is a central-action analgesic drug which administered peripherally has shown potent analgesic. It was shown in a pilot study which tramadol, when administered in the temporomandibular joint (TMJ), induces a potent antinociceptive through activation of the NO/ cGMP pathway. It has happened independent activation of opioid receptors, however. Whereas activation L-Argi…
(Only some records are available in English at this moment)
Epoxyeicosatrienoic acids (EETs) are products of arachidonic acid metabolism catalyzed by cytochrome P450 epoxygenases. These small molecules are autocrine and paracrine lipid mediators with important roles in inflammation, cardiovascular function, and angiogenesis. Recent evidence has highlighted that EETs could represent a novel therapeutic strategy for the control of inflammation. The…
| 1 / 1 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 6 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 11 / 11 | All research grants and scholarships |
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