CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
J.A.M. Barbuto graduated in Medicine by the Faculty of Medicine, University of Sao Paulo, has a Master's degree in Microbiology and Immunology, by the "Escola Paulista de Medicina" (Federal University of Sao Paulo) and a Ph.D in Immunology by the University of Sao Paulo. Currently he is an Associate Professor in the University of Sao Paulo. He has experience in cellular immunology, focusing in cancer immunotherapy, and studies mainly dendritic cells, their pathophysiology and clinical applications. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Surge una posible vacuna contra el cáncer causado por el VPH |
| Vaccine candidate designed to treat cancer caused by HPV |
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| News published in Agência FAPESP Newsletter about the researcher |
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| Articles published in other media outlets ( ): |
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The present proposal establishes the continuity and expansion of the activities of the National Institute of Science and Technology in Stem Cells and Cell Therapy, one of the National Institutes of Science and Technology created by CNPq/FAPESP in 2008. In that opportunity, we proposed the development of an extensive program of basic and clinical research to understand, isolate, culture an…
Due to the relative lack of success of the existent treatments against lung cancers, it is of utmost urgency to develop new, efficient and selective therapies against this disease that is responsible for millions of deaths worldwide. In this regard, the purpose of this proposal is the development of a novel class of drugs candidates, which might offer the possibility of a disease free lif…
Dendritic cells (DCs) constitute key elements that influence strongly the consequences of an encounter of the organism with any antigen. Immune response patterns, ranging from tolerance to antigen elimination or the establishment of immunopathological states depend on the way DCs interact with T lymphocytes. Our laboratory has been studying DCs and found many intriguing behaviors of these…
(Only some records are available in English at this moment)
The presence and function of cellular components of the innate and adaptive arms of the immune response appear to be affected differently by volatile and intravenous anesthetics, such as sevoflurane and propofol, respectively, and, consequently, are proposed to have diverse effects in the recovery of post-surgical patients. Since studies in the literature are controversial and, in general…
Among the immunotherapies, the CAR-T cell therapy has been standing out in the past few years, given the promising results obtained for hematologic malignancies. The insertion of a CAR (Chimeric Antigen Receptor) molecule in the T cells provides an antigen specific and MHC (Major Histocompatibility Complex) independent antigen recognition. The CAR-T cell products currently approved for cl…
Breast cancer, the main neoplasm that affects women in the world, despite having high cure rates when detected in its initial state still ranks in second among causes for cancer related death in women. Among the current standard-treatment possibilities, chemotherapy and hormone therapy are the ones who stand out the most, however, patients with metastatic, aggressive and/or relapsed disea…
Dendritic cells are the main professional antigen-presenting cells of the human body, having a major role in the innate and adaptive immune responses. It has been researched a lot about the effects of different cytokines on these cells, however, recent studies - highlighting the molecular biology field - suggest that knowledge about the metabolism of the dendritic cells may be essential f…
(Only some records are available in English at this moment)
Despite the pivotal impact of target therapies and immunotherapy on cancer cure rates, tumor metastasis remains a major challenge to be overcome, being the leading cause of cancer-related death worldwide. In this sense, it is crucial not just to expand our understanding about the biology of tumor cell dissemination but also to translate the knowledge acquired so far into effective therape…
Among immunotherapies, the CAR-T cell therapy has been standing out in the past few years, given the promising results obtained for hematologic malignancies. The CAR-T cell products currently approved for clinical use are obtained from autologous T cell sources. However, the production of autologous CAR-T cells faces many manufacturing difficulties, such as the extensive production time, …
Dendritic cells (DCs) are a subtype of cells specialized in antigen capture, processing and presentation, thus triggering the response of T lymphocytes. DCs may generate immunity or tolerance, depending on the extracellular signals they receive. DCs that receive tolerogenic signals, such as 1,25(OH)2D3, are characterized by their ability to generate, , CD4+CD25+FoxP3+ T lymphocytes or to…
The study is based on previous findings on a series of substituted-[N'-(benzofuroxan-5-yl)methylene] benzohydrazides which have shown potent cytotoxic effects against a variety of malignant tumor cells that overexpress MDMX protein. MDMX is responsible for the functional deficiency of p53 in tumors, like melanoma, which show this deficiency even though they do not have mutations in p53. H…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 13 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 57 / 30 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 10 / 10 | Completed scholarships abroad |
| 83 / 48 | All research grants and scholarships |
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