CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas - Modalidade Bacharelado from Universidade Estadual Paulista Júlio de Mesquita Filho (2003), master's at General Biology from Universidade Estadual de Campinas (2006) and doctorate at Morphology from Universidade Federal de Minas Gerais (2011). Has experience in Morphology, focusing on Cytology and Celular Biology, acting on the following subjects: epitélio germinativo, teleostei, morfometria testicular, célula de sertoli and capacidade suporte. (Source: Lattes Curriculum)
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Why do some fish reach sexual maturity too early, compromising their growth and reproductive quality? This is a major challenge in modern aquaculture, which aims to produce healthy, efficient, and high-performing fish. Understanding the internal signals that control the onset of puberty can help develop new strategies to improve fish farming practices.In this project, we will investigate …
The applicant is a young outstanding scientist who has published 45 articles (1569 citations, H-index = 15), supervised 5 PhD thesis, coordinated successful project grants (over 500,000 EURO), and became quite early an Associate Professor. His studies were pioneer in developing spermatogonial stem cell (SSC) transplantation in zebrafish, and showing the role of crucial growth factors, Igf…
Brazil has approximately 13.6% of the world's fresh water, represented by 12 Basins, concentrated specifically in 3 large basins, the Basins Amazon, São Francisco and Paraná. The state of São Paulo has an abundance of rivers, and its hydrographic basins are threatened by anthropic actions. Therefore, the increase in pollutants and the lack of inspection of the emission of chemical compoun…
The environmental pollution is one of the greatest dilemmas of the humanity, specially in urban areas. An improper basic sanitation and water treatment lead to daily discharge of effluents from industry and residences into the water resources. Those effluents contain toxic compounds as the polycyclic aromatic hydrocarbons (PAH) and metals. The PAHs are mainly derived from the combustion o…
Testicular organoids are three dimensional clusters derived from testicular cells that exhibit in vitro same cytoarchitecture and functionality of a testis in vivo. To achieve this, the organoids are originated from stem cells (spermatogonial stem cells) and somatic cells that recapitulate the testis morphogenesis, and mimic the complex cellular and molecular interactions present in the o…
(Only some records are available in English at this moment)
The use of pesticides is fundamental to modern agriculture in Brazil, which leads the world in the consumption of these substances. However, this practice raises concerns about the contamination of surface waters, affecting non-target organisms and possibly interfering with the endocrine systems of humans and animals. With 465 approved active ingredients, Brazil does not yet have comprehe…
proposta proporcionará ao bolsista formação científica prática em técnicas de biologia molecular, cultivo ex vivo e bioinformática, despertando o interesse pela pesquisa e promovendo sua iniciação à investigação científica em um tema de fronteira com alto potencial de impacto aplicado.O ChatGPT disse:Early sexual maturation is an undesirable trait in several fish species, as it negatively…
Fertility in males is a process that depends on the differentiation of germ cells, with the purpose of producing millions of sperm during the male reproductive life. This production is regulated by a balance between the processes of self-renewal and differentiation of Spermatogonial stem cells. Recently, lncRNAs have been recognized to play a vital role in regulating spermatogenesis, affe…
The applicant is a young outstanding scientist who has published 45 articles (1569 citations, H-index = 15), supervised 5 PhD thesis, coordinated successful project grants (over 500,000 EURO), and became quite early an Associate Professor. His studies were pioneer in developing spermatogonial stem cell (SSC) transplantation in zebrafish, and showing the role of crucial growth factors, Igf…
Spermatogenesis is a complex process involving the formation of male gametes and occurs in several phases, including cellular control, DNA replication, and genetic material separation, resulting in the production of highly specialized sperm. This process is essential for genetic variability and the maintenance of the species' chromosome number. Early sexual maturation can be problematic f…
(Only some records are available in English at this moment)
Considering that early or delayed maturation may impact aquaculture species' production, it is essential to understand how spermatogonial stem cell (SSC) activity is regulated in order to manage fish puberty onset. Endocrine and paracrine signals are essential in the SSC niche affecting the delicate balance between SSC self-renewal and differentiation. On the other hand, molecular proces…
The study of puberty in fish is specially relevant because either the premature or the late onset of the gonadal maturation are significant issues for many cultivated species. At the onset of fish puberty, signaling from the pituitary reaches the developing testis, inducing or inhibiting the expression of many factors in the spermatogonial stem cell niche, regulating the balance between g…
The Piaractus mesopotamicus, popular named as Pacu, is a Neotropical freshwater fish with high value commercial and potential to fish farming. In captivity, the males of Pacu shows a pattern of gonadal maturation similar to that seen in nature, with late sexual maturity (2-3 years). Since we have a lack of genetic information and limited knowledge about P. mesopotamicus reproduction, furt…
Organoids are tree-dimensional (3D) cell agglomerates that recapitulate de novo tissue morphogenesis, and consequently tissue cytoarchitecture and biological function of a given organ. Two-dimensional (2D) culture systems, such as organotypic cultures, are not optimal to study the complex cell-cell interaction and signaling as observed in vivo. Therefore, 3D culture system can open opport…
(Only some records are available in English at this moment)