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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Suiça
Roberto De Pasquale holds a PhD in Neurobiology, obtained in 2009 from the Scuola Normale Superiore di Pisa. He completed two postdoctoral fellowships in the United States, at Johns Hopkins University and the University of Chicago, and one postdoctoral fellowship at the University of São Paulo. Currently, he is a faculty member in the Department of Physiology and Biophysics at the Institute of Biomedical Sciences at the University of São Paulo. His research employs in vitro electrophysiological techniques to study synaptic transmission, neuronal excitability, and synaptic plasticity in the cerebral cortex and hippocampus. The goal is to understand the relationship between bioelectrical neuronal activity and brain functions such as cognition, emotional response, learning, and memory. His current research projects investigate the effects of serotonergic and purinergic modulation on excitatory and inhibitory transmission in the prefrontal cortex and hippocampus. (Source: Lattes Curriculum)
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The aging nervous system undergoes a series of modifications that predispose it to pathological changes that include memory deficits. The formation of explicit memory traces is based on the neural functions of the hippocampus. Through synaptic plasticity, this region reorganizes its circuitry, allowing the consolidation and recovery of acquired information. Hyperexcitation of the hippocam…
The prefrontal cortex (PFC) is a region involved in planning cognitive behaviors, emotional responses, and decision making. An important part of the development of this cortical area occurs during the early postnatal period. In rodents, this phase corresponds to the first three weeks of life. During this period, PFC neurons show high excitability and develop endogenous waves of excitatory…
No cerebral cortex, neural information resulting from experience shapes neural networks by reorganizing their connections as a product of the history of its activation. As part of this process, cortical neurons modify the strength of the synapses as a function of the temporal relation between pre and postsynaptic activity. This form of synaptic plasticity is called Spike-timing Dependent …
During the postnatal development of the nervous system, the synapses of the prefrontal cortex (PFC) are in a critical period with high capability of long-term potentiation (LTP). Within this time window, the PFC neurons establish many new connections, thus designing the primordial neural circuitry. It has become known that chronic stress reduces the efficacy of LTP, as well as dendritic p…
(Only some records are available in English at this moment)
The prefrontal cortex (PFC) is a region involved in the planning of cognitive behaviors, emotional responses, and decision-making. An important part of the development of this cortical area occurs during the early postnatal period. In rodents, this phase corresponds to the first three weeks of life. During this period, PFC neurons exhibit high excitability and develop endogenous waves of …
Synaptic plasticity is an important phenomenon that is in the basis of learning and memory processes. In this context, the hippocampus is a brain region relevant in some types of memory and uses plasticity to modify its connections during the process of memory traces formation. One of the types of plasticity is the spike-timing-dependent plasticity (STDP), which is mediated by the NMDA re…
Stress is related to the genesis of various neuropsychiatric diseases, such as anxiety and depression. Several changes occur in the central nervous system after exposure to stressors, such as the modulation of serotonin (5HT) release and cortisol, among other factors that compose the neural response to stress. In particular, the type 1A serotonin receptor is strongly involved in the modul…
(Only some records are available in English at this moment)
The prefrontal cortex (PFC) is an essential brain region involved in cognitive functions and emotional regulation. Like other cortical areas, a significant portion of its development occurs during the early postnatal period, and any disruptions to this developmental process may contribute to the onset of psychiatric disorders. Previous studies have provided evidence that the PFC exhibits …
| 1 / 1 | Ongoing grants |
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| 1 / 1 | Ongoing scholarships in Brazil |
| 5 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 12 / 12 | All research grants and scholarships |
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