CV Lattes
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ORCID
Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas-modalidade Biofísica from Universidade Federal do Rio de Janeiro (2009). Has experience in Byophysics, focusing on Byophysics (Source: Lattes Curriculum)
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The molecular chaperone HSP70 is the most abundant chaperome member. In the vascular context there are only two know clients in endothelial cells (ECs): CLEC14a (C-type lectin domain family 14 member) and nucleolin, proteins associated to tumor angiogenesis. Loss-of-function experiments in static ECs promotes broader general effects like impairment of migration, tube formation, phosphoryl…
The 70 kDa heat shock protein (HSP70) is a versatile molecular chaperone that plays a role in protein folding, translocation of proteins to organelles, protein degradation by the ubiquitin proteasome system and also by autophagy. The HSP70 plays a role in endothelial cell migration VEGF2 induced and is important for tube formation showing its role in angiogenesis. Most of these studies fo…
Chronic thromboembolic pulmonary hypertension (TEPH) is characterized by the formation of intraluminal thrombus leading to right ventricular overload. It is characterized by the presence of anticardiolipin antibodies, factor VIII, macrophage chemo-attracting protein, endothelin-1 and low levels of thromobomodulin [1]. The first line of treatment is anticoagulation and endarterectomy (PEA)…
(Only some records are available in English at this moment)
Several intracellular chaperones have been shown to be secreted by distinct cellular types, including vascular, immune and tumor cells. Protein disulfide isomerase (PDI), as well as 70 and 90kDa heat shock protein (Hsp70 and Hsp90) families play extracellular roles in pathological conditions such as thrombosis, vascular remodeling and cancer survival and metastasis generation. Inhibition …
| 1 / 1 | Ongoing research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 6 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 9 / 9 | All research grants and scholarships |
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