CV Lattes
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Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas from Universidade Federal de São Carlos (2003), master's at Genética e Evolução (Conceito CAPES 4) from Universidade Federal de São Carlos (2006) and doctorate at Genética e Biologia Molecular (Conceito CAPES: 7) from Universidade Estadual de Campinas (2012). Has experience in Genetics, acting on the following subjects: il-7r, leucemia linfóide aguda, imunoterapia, interação de proteínas and hibridomas. (Source: Lattes Curriculum)
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The ectoenzyme CD73 plays an important role in the conversion of ATP to adenosine, promoting immune suppression and favoring tumor progression. Although its role is well-established in several cancers, its importance in pediatric cancers is still underexplored. Monoclonal anti-CD73 antibodies have the potential to reverse this suppression and improve anti-tumor responses, offering a promi…
The lymphoid leukemias are hematologic neoplasms in the B and T lineages and are the major cause of infant death caused by cancer. About 10% of the ALL-T and 2% of the ALL-B present a leukemogenic mechanism caused by activating mutations in the gene encoding the hIL7R± protein (± chain of the human 7 interleukin receptor). The IL7R± is a protein expressed on the lymphocyte surfaces, it is…
The use of immunocompetent murine models is a frequent and necessary practice in various biomedical research. However, critical genetic and immunological differences between the murine and human systems have hindered the development of in vivo studies that require a uniquely human immunological response. One way to overcome this difficulty is to generate humanized mice from immunosuppress…
(Only some records are available in English at this moment)
When it comes to cancer, the pediatric category represents about 3% of registered cases, sampling an incidence that varies in world populations between 70 and 120 cases per million of inhabitants each year. From the 1960s onwards, the adoption of treatment techniques multimodality brought a significant increase in survival for patients affected by these malignancies, however, cure rates f…
(Only some records are available in English at this moment)
Humanized mice (HuMice) are murine models in which the immune system is reconstituted with human immune cells. THX (Truly Human Xenograft) mice are humanized models conditioned with the administration of 17-¿-estradiol (E2), developed at the University of Texas Health Science Center under the supervision of PhD. Paolo Casali. THX mice exhibit elevated circulating human immunoglobulins (Ig…
Overexpression of particular receptors (e.g. receptor tyrosine Kinase HER2) or mutations modifying the function of some receptors (e.g. interleukin-7 receptor IL7R) have been described to stimulate cancer cell growth and in some cases are associated with increased disease recurrence and worse prognosis. Therapeutic IgG antibodies targeting overexpressed or mutated receptors on tumor cells…
| 5 / 5 | Ongoing scholarships in Brazil |
| 7 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 14 / 14 | All Scholarships |
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