CV Lattes
ResearcherID
ORCID
Google Scholar Citations
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduate at Odontologia from Universidade de São Paulo (2001), master's at Odontology from Universidade de São Paulo (2002) and PhD at Histology from Universidade de São Paulo (2006). Has experience in Morphology, focusing on Celular and Tumoral Biology, acting on the following subjects: glandular tumors, extracellular matrix, extracellular matrix receptors and extracellular matrix proteases (MMPs and ADAMTS). (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Breast cancer is the most common type of tumor among women, with the triple-negative subtype (TNBC) being the most aggressive, associated with high mortality rates and lower survival in metastatic cases. Metastasis occurs through the spread of the tumor via circulation, involving processes such as intravasation and extravasation of tumor cells through the endothelium. Studies suggest that…
Breast cancer is the most common type of cancer in women, presenting high incidence and mortality worldwide. The most aggressive and invasive subtype of breast cancer is triple-negative (TN), showing low response to therapy and poor prognosis when metastatic. Metastasis is one of the hallmarks of cancer, consisting of a multistep phenomenon started by the shedding of cancer cells from the…
The Science Xpression workshop will be taught entirely in English and will have practical and theoretical activities. We will make a wide dissemination of this workshop in the Post- Graduation from USP and beyond. This activity is expected to be part of a Postgraduate Course in our Program in Systems Biology and will benefit both students and students from other Postgraduate studies. This…
(Only some records are available in English at this moment)
Uveal melanoma (UM) is the most aggressive form of ocular cancer, poses a formidable challenge due to its high metastatic propensity, a leading cause of patient mortality. Effective therapies for UM metastasis remain elusive. Based on solid preliminary data, in this project I posit that loss of 15-hydroxyprostaglandin dehydrogenase (HPGD), a tumor suppressor gene, promotes UM aggressivene…
Breast cancer is the most common type of female cancer worldwide, with metastasis accounting for the majority of deaths, high recurrence, and poor prognosis rates. While not all of the mechanisms underlying the complex process of metastasis are fully understood, fluid shear stress, endothelial cells, and tumor-endothelial cell adhesions have all been implicated. Tumor cells adhere to endo…
Breast Cancer is the second Cancer type that most affects women. Of these patients, metastasis is one of the main causes of death. The angiogenesis, the entrance and exit of tumor cells from the circulation are fundamental steps in metastasis. Our group observed that incubation of tumor cells in acid pH increased the expression of genes involved in angiogenesis. Acid pH and other adverse …
In 2018, about 9 million cancer-related deaths were recorded and about 18 million new cases were diagnosed. The cancer is known as a multi-step process, which the last step in tumor progression is metastasis, a tumor spreading from a primary site to a distinct organ. This progress is aided by the formation of environments called pre-metastatic niches, whose main function is the preparatio…
Ovarian carcinoma is the leading cause of gynecological neoplastic death, being associated primarily with deregulation of sex hormones. The progression of cancer depends not only on abilities acquired by cancer cells, but also the interaction between cells and their microenvironment. The components of the extracellular matrix (ECM) are involved in several aspects of tumor biology, providi…
(Only some records are available in English at this moment)
Increase in endothelial activation and permeability are crucial steps in metastasis. In the tumor microenvironment, cancer cells typically suffer endoplasmic reticulum stress and extracellular acidosis. These conditions are associated with cancer progression and treatment resistance. Large extracellular vesicles (LEV) are important mediators in the communication between cancer cells and e…
The progression of cancer depends on the interaction between the cells and their microenvironment. ADAMTSs (adamalysin-thrombospondin) are secreted proteases dependent on Zn2+/Ca2+ and participate in many physiological and pathological processes. Progesterone increases ADAMTSs gene and protein expression and reduces the migratory and invasive capacity of the ovary cells when compared to u…
Mammary tumors are the second most frequent type of neoplasm in worldwide among women. In extracellular matrix quantitative and qualitative changes occur resulting in remodeling, originated from the activity of proteases secreted by mammary cells in microenvironment. Metalloproteinases belonging to the ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) family are well k…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 12 / 9 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 15 / 9 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 34 / 25 | All research grants and scholarships |
| Associated processes | |