Kely Catarine Matteucci

• Abstract

  In the last 15 years, my lab has dedicated to understand the mechanisms by which Plasmodium infection stimulate the innate immune responses and what is the outcome of these responses in host resistance to infection and pathogenesis of Malaria. The current research program includes three projects around a main theme, which is "Immunological mechanisms of host resistance and disease in Mala…

  Immunological mechanisms of resistance and disease in Malaria, BP.PD

• Abstract

  The autophagy is a homeostatic process cell, where misfolded proteins and damaged organelles are degraded. The autophagy can also be enabled when there is a lack of nutrients or lack of energy (ATP), degrading macromolecules to suppress the lack of these components. In infectious processes, the autophagy helps in the control of microorganisms, which are involved by autophagosomes that fus…

  Role of autophagy in the control of infection by Trypanosoma cruzi and the influence of the innate immunity receptors in this process, BP.DD

• Abstract

  Autophagy is a homeostatic process that occurs in the cell, where misfolded proteins and damaged organelles are degraded. This process can also occur upon lack of nutrients and energy (ATP), leading to the degradation of macromolecules to compensate the lack of these components. In infectious processes, the autophagy helps in the control of microorganisms, which are involved by autophagos…

  Influence of PRRs in the modulation of autophagy in Trypanosoma cruzi infection and its consequences in the activation of macrophages and dendritic cells, BP.MS

(Only some records are available in English at this moment)

• Abstract

  Malaria, caused by parasites from the genus Plasmodium, remains a major global health concern with millions of reported cases and deaths annually. The innate immune response involves PRRs that recognize malarial PAMPs and DAMPs, including those that promote the activation of cGAS-STING pathway. STING plays a pivotal role in immune responses against Plasmodium, inducing type I interferons …

  Role of STING pathway in interplay with TNF signalling and glucose metabolism during malaria, BE.EP.PD