Marcelo Fiori Marchiori

• Abstract

  The phosphoinositide 3-kinase (PI3K)/alpha-serine/ protein kinase B (Akt)/mammalian rapamycin target (mTOR) pathway, better known as PI3K/Akt/mTOR, is an important intracellular signaling pathway directly related to the control of cell cycle, and consequently to various pathologies related to aging and longevity, such as cancer, type 2 diabetes (DM2), heart disease and neurodegenerative d…

  Planning and synthesis of novel PI3K/mTOR double inhibitors and applications in neurodegeneration studies, BP.DR

• Abstract

  Mucins are glycoproteins WITH high molecular weight that possess as fundamental characteristic linkage between sugar ±GalNAc and amino acid residues Ser/Thr (±GalNAc-Ser/ Thr). In tumors mucin production is dysregulated, once their biosynthetic mechanisms are impaired with consequent alteration in the O-glycosylation pattern. As result abnormal and incomplete glycans are formed, which are…

  Synthesis of mucin glycopeptide containing tumor antigen analogue with potential therapeutic applications in cancer, BP.MS

• Abstract

  Mucins are highly glycosylated O-glycoproteins that contain repeated motifs in typical tandem, rich in serine (Ser) and threonine (Thr), which represent potential sites for abundant glycosylation. Alpha-Dystroglycan (alpha-DG) mucins contain the tetrasaccharidic structural motif Neu5Acalpha2-3Galbeta1-4GlcNAcbeta1-2Manalpha-O-Ser/Thr biosynthesized by specific glycosyltransferases enzymes…

  Synthesis of glycosylated amino acids related to tumor and alpha-dystroglycan mucins, BP.IC

(Only some records are available in English at this moment)