CV Lattes
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Sociedade Brasileira para o Progresso da Ciência (SBPC) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor in the Department of Biochemistry at the Paulista School of Medicine (EPM) of the Federal University of São Paulo (Unifesp) and Vice-Director of EPM-Unifesp (2023-2027). She has dedicated her career to neurobiology, working on the biofabrication of 3D systems for studying the central nervous system, with an emphasis on neurodegenerative diseases and neurodevelopment. She holds a biomedical degree from EPM, a master's, Ph.D., and postdoctoral training in Molecular Biology from Unifesp, as well as a master's in the History of Science from PUC-SP. She completed a postdoctoral fellowship in neurobiology at Harvard Medical School / Dana-Farber Cancer Institute (DFCI). She is an advisor in the Graduate Program in Molecular Biology at EPM-Unifesp, having served as coordinator (2015-2022) and vice-coordinator (2022-2023). She is a member of the management committee of PROFBIO (Professional Master's in Biology Teaching). She coordinates the INCT MODEL3D (National Institute of Science and Technology for Modeling Complex Human Diseases with 3D Platforms) (2022-2027) and was a researcher at INCT REGENERA (INCT for Regenerative Medicine). She is a board member of SBPC (Brazilian Society for the Advancement of Science; 2021-2025) and was president of SBBC (Brazilian Society for Cell Biology; 2020-2024). She is a member of the Deliberative Council (CD) of CNPq, representing scientific societies in the life sciences. She was responsible for organizing the São Paulo School of Advanced Science (SPSAS) in Stem Cell Biology (FAPESP), held in partnership with the International Society for Stem Cell Research (ISSCR) (2023).Co-host of the Podcast Alzheimer Connection (https://open.spotify.com/show/1cAheWrzYNx35w8GfyiVLg) (Source: Lattes Curriculum)
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The blood-brain barrier (BBB) is a highly selective membrane composed of endothelial cells, pericytes, and astrocytes. Its function is to regulate the exchange of substances between the brain and the bloodstream, protecting neural tissue from the entry of neurotoxic molecules, viruses, and other agents that may harm brain tissue. The BBB also regulates the exit of molecules from the brain…
The concept of organ-on-a-chip refers to different types of in vitro modeling or reproduction of tissues and organs by combining cells and biocompatible material. This approach has become an attractive alternative for various studies, such as drug testing. The initial push was the worldwide effort to reduce the number of lab animals used in research, by the application of the 3R's - repla…
Day 1 - Welcome and Course Overview, FAPESP Presentation, Day 2 - Topic 1 - Introduction to Stem Cell Biology, Topic 2 - Introduction to Development, Professional Development, Day 3 - Topic 2 - Introduction to Development, Topic 3 - Pluripotency and Reprogramming Professional Development, Day 4 - Topic 4 - Adult Stem Cells and Regeneration, Topic 5 - Cancer Stem Cell, Presentations by stu…
(Only some records are available in English at this moment)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a gradual decline in memory and cognition, among other clinical hallmarks. The brain of an AD patient presents abnormal beta-amyloid (Ab) deposition in the extracellular matrix and intraneuronal neurofibrillary tangles. Familial AD (FAD) is genetically inherited and less frequent than sporadic AD (SAD), which compri…
The conventional 2D cell culture system has been used for studies of various aspects of the Central Nervous System. However, this type of culture does not reproduce the three-dimensional (3D) framework in which cells are found in native tissue. In this context, 3D bioprinting technology overcomes the limitations of the 2D system, providing an environment closer to the physiological one. S…
The study of in vitro cell culture together with the multielectrode arrays (MEA) technique has provided significant advances in our understanding of the neurobiological basis of several diseases, such as the Autism Spectrum Disorder (ASD). MEAs enable high precision recording of the electrical activity of neuronal populations, allowing for highly detailed assessment of action and local fi…
(Only some records are available in English at this moment)
The increase in life expectancy in recent decades, while reflecting positive public health measures, poses new challenges due to the increased incidence of chronic non-communicable diseases. Diabetes, cardiovascular diseases, and neurodegenerative diseases, including Alzheimer's disease (AD), are among the main diseases that affect the health of the world's population today. AD can be cla…
The increase in life expectancy in recent decades, while reflecting positive public health measures, poses new challenges due to the increased incidence of chronic non-communicable diseases. Diabetes, cardiovascular diseases, and neurodegenerative diseases, including Alzheimer's disease (AD), are among the main diseases that affect the health of the world's population today. AD can be cla…
Traditionally, 2D cell culture models are used to study different aspects of the CNS. However, this type of culture does not reproduce the three-dimensional (3D) framework in which the cells are found in native tissue. In this context, 3D bioprinting makes it possible to overcome these limitations, providing an environment closer to the physiological one. This technology has been applied …
(Only some records are available in English at this moment)
The neurovascular unit (NVU) is a complex, dynamic structure made up of neurons, glia, and vascular cells. Recent data revealed how glia interactions might be fundamental for NVU function. Despite the vast knowledge of glia biology, some fundamental aspects remain unknown. For instance, the exact physiological implications of different glial lineages in neuron-glial networks and their con…
Electrocardiographic (ECG) changes, and arrhythmias are found in 40-100% of subarachnoid hemorrhage (SAH) patients, even in a low prevalence of coronary artery disease. Cardiac arrhythmias are associated with an increased risk of prolonged hospital stay and poor outcomes or death after SAH. Therefore, investigating the brain-heart interaction after stroke is highly clinically significant.…
Current in vitro models of the Central Nervous System (CNS) present several limitations regarding poor representation of three-dimensional (3D) environments and as so, fail to reproduce the tissue's dynamics in health and disease. As an alternative to two-dimensional (2D) cell cultures, 3D bioprinting represents a new technology to produce artificial, tissue-like structures with the possi…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 24 / 21 | Completed research grants |
| 8 / 8 | Ongoing scholarships in Brazil |
| 45 / 37 | Completed scholarships in Brazil |
| 9 / 9 | Completed scholarships abroad |
| 88 / 77 | All research grants and scholarships |
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