CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
M.D. (1962) and Ph.D. in Biochemistry (1966) by the Medical School of the University of São Paulo. Has experience in Biochemistry and Molecular Biology, focusing on the surface membrane of Trypanosoma cruzi, the agent of Chagas' disease. His laboratory was the first to describe the novel class of molecules called GIPLs (originally LPPG) and the largest glycoprotein family belonging to the gp85/trans-sialidase superfamily on the surface of the parasite, and probably involved in adhesion and invasion in the host. For 30 years maintained active collaboration with argentinean groups and trained many post-docs from this country in his laboratory. For that reason he was awarded with the title of Doctor Honoris Causa of the University of Buenos Aires. He was the President of the Brazilian Technical Committee on Biosafety (2006-2010). In 2014 he was awarded the prize Almirante Álvaro Alberto, the most prestigious prize for scientific achievements in Brazil. In 2021 received the title of Professor Emeritus of the University of São Paulo (USP). (Source: Lattes Curriculum)
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Chagas' disease is a chronic illness and an important health issue in Brazil, Latin America and, more recently, in the world due to the steady increase in migration to developed countries. It is estimated that 200,000 people will die due to Chagas' disease in the next five years. Since there is no vaccine and existing therapies rely mostly on old drugs with limited efficacy and toxic side…
Chagas disease is a chronic illness and an important health issue in Brazil, Latin America, and more recently in the world due to the steady increase in migration to developed countries. There is no vaccine and existing therapies relay mostly on old drugs with limited efficacy and toxic side effects. The conclusion of the genome of Trypanosoma cruzi strain CL Brener has been greeted as a …
The acute phase of Chagas Disease presents a generalized infection, with Trypanosoma cruzi present in almost all the organs and in the interior of different types of cell: smooth, skeletal and cardiac muscle fibers, fibroblasts, endothelial, glial, Schwann cells, neurons, macrophages and adipocytes. The peripheral nervous system is compromised, as, for example, in the alterations that occ…
(Only some records are available in English at this moment)
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