CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Pharmacy from the University of São Paulo (USP), with a Master's Degree in Immunology from USP and a PhD in Microbiology and Immunology from Escola Paulista de Medicina (UNIFESP). Completed postdoctoral studies at the Liverpool School of Tropical Medicine in Molecular Biology of Toxins. Researcher at the Butantan Institute, she works in the field of Toxinology, focusing on the structure and function of venom metalloproteinases. Collaborates with international groups and groups from the Amazon region addressing ecological, evolutionary aspects of snakes and envenomation and treatment of human envenomings. Supervises MSc and PhD students and presents several publications in indexed international journals. (Source: Lattes Curriculum)
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Currently, the northern region of Brazil is the one with the highest incidence and severity of snakebites in the country. Bothrops atrox snake is responsible for the largest number of cases and is found throughout the Amazon, with other species also involved in accidents such as B. brazili, B. taeniatus, B. bilineatus and Bothrocophias hyoprora occurring mainly in Acre and Crotalus duriss…
The blood coagulation and fibrinolytic systems have been convergent acted upon by toxic organisms on multiple occasions. Brazil is one of the major countries affected by snakebite and the leading cause of snakebite is from species with coagulotoxic venoms, particularly in Bothrops snakes, which predominate in the whole Brazilian territory. However, the current knowledge about coagulotoxic…
The expansion and adequacy of the infrastructure for connectivity and the institutional database are extremely relevant actions to allow the scientific activities of Instituto Butantan to be executed with maximum support. These actions allow the implementation of new and better technologies, as well as reduce the obsolescence of equipment and infrastructure. (AU)
This project will determine how secondary key innovations within the venom system contribute to diversification patterns in the advanced snakes and test for biases in the genetic pathways underlying rapid phenotypie evolution in venoms as a means for understanding the mechanism underlying the process of diversification in this diverse group. In the first part, we will test for relationshi…
(Only some records are available in English at this moment)
The northern region of Brazil is responsible for the highest incidence and severity of ophidian accidents in the country. Bothrops atrox snake is responsible for the largest number of cases, presenting a composition of venom rich in Metalloproteinases (SVMPs). SVMPs have the ability to hydrolyze and bind extracellular matrix proteins (ECMs), which trigger most of the local lesions that oc…
Proteolytic and phospholipases enzymes are key components in snake venoms that act to capture prey through distinct mechanisms: proteolytic enzymes target important hemostasis control targets while phospholipases act on different muscle or neuronal receptors, inducing paralysis of prey and myotoxicity. Besides the capture of prey, these enzymes are supposedly involved in the digestion of …
Proteolytic enzymes and phospholipases are key components in the venom of snakes, especially in viperids. They are involved in the capture and digestion of prey acting on several targets important for the control of hemostasis and also contribute to the digestion of tissues. In this project, we will evaluate the activities of phospholipases, serine proteinases and metalloproteinases in th…
(Only some records are available in English at this moment)
The northern region of Brazil is responsible for the largest incidence of snakebite accidents in the country. The accidents in the region have worst prognosis due to the difficulty of moving fast on hospital for treatment, and also the low capacity of antivenoms to neutralize the local effects. Bothrops atrox is the specie responsible for the majority of snakebites in the Amazon and the v…
The variability in venom composition is suggested as a key factor in the occupation of different ecological niches by the advanced snakes. However, the molecular mechanisms underlying snake venom variability are still not entirely clear and this information provides important clues to the understanding of the main mechanisms of adaptation to different environments. The venom from rattlesn…
Bothrops envenomation often includes local effects and systemic reactions represented mainly by coagulation disturbances. SVSPs, SVMPs, PLA2s and CTLs are main protein families involved in these disturbances. These toxins are able to act on components of the coagulation cascade, promote hemorrhage and interfere by different ways in the formation of the hemostatic plug and platelet aggrega…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 18 / 10 | Completed research grants |
| 28 / 11 | Completed scholarships in Brazil |
| 5 / 4 | Completed scholarships abroad |
| 52 / 26 | All research grants and scholarships |
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