CV Lattes
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Universidade de São Paulo (USP). Faculdade de Zootecnia e Engenharia de Alimentos (FZEA) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Medicina Veterinária from Universidade de São Paulo (2003) and doctorate at Veterinary Medicine from Universidade de São Paulo (2008). Has experience in Veterinary Medicine, focusing on Veterinary Medicine, acting on the following subjects: guaraná, quimioprevenção, paullinia cupana, hepatocarcinogenese and pcna. (Source: Lattes Curriculum)
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The annotation and analysis of immunoglobulin (IG) and T cell receptor (TR) genes in veterinary species are vital for improving the diagnosis and treatment of immune-related diseases, particularly in companion animals like dogs and cats affected by lymphoma. These studies provide critical insights into the evolutionary development of adaptive immune systems across species, enhancing under…
In veterinary medicine, histopathological analysis is still the most used exam in the diagnosis of neoplasms in dogs. However, significant challenges remain, both in determining the origin of neoplastic cells and in monitoring cancer patients, due to the limitations of this technique. Therefore, the development of more agile, efficient and less invasive diagnostic methods, suitable for in…
The increase over the years in the number of people with cancer and cancer deaths, as well as the existence of cancers in different organs with heritable causes or not, are very similar to what happens in other animal species, especially those sharing the human environment as dogs and cats. In Brazil there are 55,1 and 24,7 million living dogs and cats respectively. Considering that 1 in …
(Only some records are available in English at this moment)
The aim of this proposal is to bring an outstanding Visiting Researcher (Dr. David J. Argyle) in the area of Translational Veterinary Oncology to open new possibilities for the ongoing research projects at the Laboratory of Comparative and Translational Oncology (LOCT-USP) of the School of Animal Science and Food Engineering, University of Sao Paulo, Campus Fernando Costa at Pirassununga-…
This equipment has the main function the analysis of specific cell populations in a heterogenous sample, based on their specific properties such as markers or enzyme activity. It will be a multi-user equipment since it can be used for several different applications when one wants to characterize cell biology. (AU)
(Only some records are available in English at this moment)
In oncology, the Newcastle disease vírus (NDV) stands out as an oncolytic and non-pathogenic agent in mammals. The use of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) has also shown great potential as it: stimulates the production of cytokines such as NF-¿ (Tumor Necrosis Factor Alpha) and IFN-¿ (Interferon Alpha); enhances antibody-dependent cellular cytotoxicity (ADCC); and…
The evaluation of cancer-related miRNA expression has facilitated the development of precision diagnostic and prognostic tests. Multicentric lymphoma is the most frequent hematopoietic cancer in dogs and exhibits highly variable behavior, as patients diagnosed with the same histological subtype may show different therapeutic responses and survival rates. Therefore, the aim of this project…
This project aims to establish the reverse genetics platform for recombinant NDV production and generation of rNDVs with enhanced oncolytic and immunostimulatory effects in canine mammary cancer cells. Using In-Fusion cloning technology, we intend to generate 3 recombinant NDV strains expressing granulocyte-macrophage colony-stimulating factor (GM-CSF), thymidine kinase (TK), and cytosine…
(Only some records are available in English at this moment)
Around 90% of oral melanomas in dogs are malignant and have a high rate of invasiveness with a propensity to metastatic to the lungs and regional lymph nodes. The life expectancy of animals affected by the disease is reduced, even after surgical treatment, reaching a maximum survival of 18 months. In this scenario, immunotherapy has shown promise and its success is precisely because it ca…
The human genome encodes more than 500 protein kinases, of which the majority remain to be explored for their structure and function. Also, there are at least 91 protein kinases that represent likely cancer drivers 1 and dysregulation of kinase function is a hallmark of most human cancers. As a result, kinase inhibitor development has been one of the major focuses of drug development duri…
3D cells cultures have the advantage of mimicking the tumor microenviroment, and this makes these models ideal for evaluation of new cancer therapies, obtaining results that can be considered more reliable compared to 2D cultures in cell monolayers. Newcastle Disease Virus (NDV) is an oncolytic virus, non-pathogenic for mammals, which selectively induces oncolytic effects in cancer cells,…
(Only some records are available in English at this moment)
Accurate measurement of immune repertoire sequence composition, diversity, and abundance is crucial for understanding repertoire responses in infections, vaccinations, and cancer immunology. This knowledge could also aid in identifying novel molecular targets, which can be helpful in terms of developing tools from the benefit of precision oncology for cats. The evaluation of immune repert…
Metabolomics is a promising alternative aiming to define markers for residual feed intake (RFI) for selection of feed efficiency in beef cattle in a more accurate, faster, and cost-effective way. Studies evaluating metabolites associated with feed efficiency in beef cattle are still scarce and, for the most part, carried out on a small scale, generating discoveries that lack statistical r…
Exists at least 356 dog breeds recognized by the Federation Cynologique Internationale (FCI). The diversity of phenotypes associated with canine breeds reflects a large genomic variation, which has been shown to be much greater than in humans. Genomic variation also affects the immune repertoire, causing differences in the adaptive immune response, influencing the repertoire of B cell rec…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing grants |
| 9 / 5 | Completed research grants |
| 8 / 8 | Ongoing scholarships in Brazil |
| 25 / 19 | Completed scholarships in Brazil |
| 9 / 9 | Completed scholarships abroad |
| 55 / 45 | All research grants and scholarships |
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