CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba (FOP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
After graduating at the Piracicaba Dental School, University of Campinas (FOP-UNICAMP) in 1994, I received my master (1996) and PhD (1999) in Oral Biology and Pathology from the same institution. I became an associated professor in 2006 and currently I am professor in Pathology of the Department of Oral Diagnosis, FOP-UNICAMP. I spent one year as research fellow (sandwich fellowship) in the University of Maryland Dental School (1998-1999), where I have conducted a series of experiments to understand the cellular and molecular events related to the gingival overgrowth in hereditary gingival fibromatosis, and other two years (postdoctoral fellow) working with Professor Heide L. Ford in the School of Medicine, University of Colorado Denver (2002-2004), exploring the involvement of the SIX1 homeobox gene in the development and tumorigenesis of the mammary glands. In 2022, the Faculty of Medicine of the University of Helsinki awarded me with the title of Doctor Honoris Causa from for my international contribution on oral cancer. I am Specialty Chief Editor of section Oral Cancer in Frontiers in Oral Health, associate editor of Journal of Oral Pathology and Medicine, and reviewing editorial board member of the Medicina Oral, Patologia Oral y Cirugia Bucal, Dentistry Journal, and Journal of Clinical and Experimental Dentistry. At FOP-UNICAMP, I was head of the Department of Oral Diagnosis, coordinator of the Graduate Program in Estomatopatologia, and vice coordinator of the Graduate Programs. I am currently member of the Internal Commission of Biosafety in Genetically Modified Organisms (CIBio-FOP) and PI of the molecular biology laboratory of FOP-UNICAMP. Member of the Area Panel in Health Sciences (Dentistry) at FAPESP. (Source: Lattes Curriculum)
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Oral squamous cell carcinoma (OSCC) is a heterogeneous and aggressive tumor, often diagnosed in advanced stages, where the treatment requires the administration of chemotherapy. Despite advances, several challenges can occur during treatment, including the acquisition of resistance to chemotherapy drugs. In this sense, a complete understanding of the mechanisms associated with chemoresist…
During oral carcinogenesis, the neoplastic cells acquire an aggressive phenotype, resulting in an increase in motility, in the ability to invade surrounding tissues and to metastasize. Metastatic spread of solid tumors is often initiated by the reactivation of an important embryonic developmental program, the Epithelial-Mesenchymal Transition (EMT). EMT has been associated with the acquis…
The aim of this proposal is to receive the Professor Tuula, University of Oulu and University of Helsinki, both in Finland, as Visiting Researcher in the Faculdade de Odontologia de Piracicaba-UNICAMP, with the objective of consolidating our collaboration in the field of aggressiveness and prognostic markers for oral cancer. Oral cancer, represented in more than 90% of cases by oral squam…
Despite the improvement in the diagnosis and treatment of patients with oral squamous cell carcinoma (OSCC), the 5-year survival rate remains around 50-60%, without significant changes in the last decades. The treatment decision and patient's prognosis relies on clinical parameters (TNM system) and histopathological features, tools that have not been shown to be widely effective. In that …
(Only some records are available in English at this moment)
Nonsyndromic oral clefts, the most common birth defects in the craniofacial region, exhibit a variable prevalence worldwide, often influenced by genetic predisposition of population. There are 3 main types of oral clefts, however, due to its low frequency, few studies have been exclusively performed with nonsyndromic cleft palate only (NSCPO), limiting the knowledge about the genetic risk…
Oral squamous cell carcinoma (OSCC) is one of the most prevalent tumors worldwide, which places it as a major public health problem. Understanding the biological mechanisms and factors that control its aggressive behavior, including situations of acquisition of epithelial-mesenchymal transition (EMT) and chemoresistance to cisplatin, is essential for the development of new and more effect…
The lack of consistent biomarkers for oral squamous cell carcinoma (OSCC) represents a major obstacle to individualizing treatment. Recently, interleukin 17F (IL-17F) has been implicated in the development of cancers in different organs. In OSCC, IL-17F levels were associated with a better prognosis and demonstrated predominantly antitumor effects, however, an association with disease pro…
The patients affected by non-syndromic cleft lip with or without cleft palate (NSCL±P)have a higher incidence of tooth agenesis, which increases the aesthetic and functional complications, requiring more complex rehabilitation plans. Evidence suggests a connectionbetween tooth agenesis and NSCL±P due to shared genes and signaling pathways related to tooth and lip/palate development. One o…
The orofacial cleft is the most common malformation in the face, with a prevalence between 0.36 and 1.54 per 1,000 live births in the Brazilian population. With a multifactorial etiology, nonsyndromic orofacial clefts are caused by interactions between environmental factors, such as smoking and medications, and genetic factors, with one of the most studied genes being the interferon regul…
(Only some records are available in English at this moment)
Towards the precision medicine era, the absence of reliable biomarkers for oral squamous cell carcinoma (OSCC) remains a significant challenge. Recent studies have linked interleukin 17F (IL-17F) predominantly to improved OSCC outcomes, but its main receptor, IL-17RC, has been far less explored. To investigate the prognostic value of IL-17RC, we evaluated the expression of IL-17RC in samp…
| 2 / 2 | Ongoing grants |
| 17 / 14 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 23 / 14 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 45 / 33 | All research grants and scholarships |
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