CV Lattes
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Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Fisica from Universidade de São Paulo (2000), master's at Physics from Universidade de São Paulo (2003) and doctorate at Physics from Universidade de São Paulo (2006). Has experience in Biochemistry, focusing on Chemistry of Macromolecules, acting on the following subjects: liver isozyme, glutaminase and glutaminase interacting protein (gip). (Source: Lattes Curriculum)
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To sustain the high proliferative rate, tumor cells have an increased demand for biosynthetic precursors used in the synthesis of macromolecules that will compose the daughter cells. For this, tumors consume a large amount of glucose and glutamine, mainly. The alteration in nutrient metabolism has been related to enzyme filamentation, a process conserved from yeast to mammalian cells, but…
The outstanding progress in structural biology made possible by single particle cryo-electron microscopy (cryo-EM), originated the so-called "resolution revolution," mainly due to its ability to provide high-resolution structural information of large and dynamic protein complexes. Recently, Brazil has acquired a state-of-the-art Titan Krios microscope, which, when in operation at the Nano…
This proposal is divided in two main parts, as determined by the protein subjects: (1) it aims at the crystallization and determination of the crystal structure of the human mitochondrial pyruvate carrier; (2) it aims at the structural characterization of the human VDAC2-Bak complex from mitochondrial outer membrane by single particle cryo-electron microscopy. (1) The active transport of …
Pyruvate is the end product of cytosolic glycolysis and has a number of possible intracellular fates, the major one being mitochondrial transport, a critical step in carbohydrate, amino acid, and lipid metabolism. Two internal mitochondrial membrane (IMM) proteins, named MPC1 and MPC2, were identified as the proteins essential for the transport of pyruvate in yeast (S. cerevisiae), Drosop…
(Only some records are available in English at this moment)
Cancer cells exhibit increased glycolytic and glutaminolytic pathways, consuming glucose and glutamine at high rates. The intensification of glycolysis (Warburg effect) and glutaminolysis provides essential intermediates for the synthesis of amino acids, nucleic acids, and lipids, as well as energy, glutathione, and NADPH for redox homeostasis. Glutamine also contributes to maintaining th…
Ascorbic acid (AsA), commonly known as vitamin C, is a multifunctional molecule with crucial roles in cellular redox control in both plants and animals. Among plants, the Amazonian species Myrciaria dubia (camu-camu) is notable for its exceptionally high AsA content, ranging from 1 to 3 g per 100 g of pulp, making it a promising source for nutraceutical and biotechnological applications. …
Self-assembly of metabolic enzymes into filaments and supramolecular structures coincides with metabolic changes and has been most widely described in bacteria and yeast, with few examples in mammalian cells. Currently, it is believed that the formation of non-membranous compartments may also play a critical role in regulating metabolic networks. A recent study on filament-forming yeast e…
This proposal for a Master's scholarship seeks to enable the research activities expected in the FAPESP-Conicyt grant 2019/13318-5. The outstanding progress in structural biology made possible by single-particle cryo-electron microscopy (cryo-EM) originated the so-called "resolution revolution" for its ability to provide high-resolution structural information of large and dynamic protein …
The phase problem is notorious in X-ray protein crystallography. Fundamentally, technological limitations on the detection systems result in the loss of information on the phases of the waves scattered constructively by the components of the crystal. As a consequence, the direct calculation of the electron density distribution function in the unit cell is impaired. Currently, two experime…
The phase problem is notorious in X-ray protein crystallography. Fundamentally, technological limitations on the detection systems result in the loss of information on the phases of the waves scattered constructively by the components of the crystal. As a consequence, the direct calculation of the electron density distribution function in the unit cell is impaired. Currently, two experime…
(Only some records are available in English at this moment)
The determination of the molecular structure of membrane proteins by cryo-electron microscopy (cryo-EM) represents the current frontier in the field of structural biology. Recent advances in detector technologies and the development of powerful maximum likelihood image processing routines have allowed for the routine description of high-resolution structures of biomolecules (> 4 Å); this …
The active transport of glycolytic pyruvate across the human inner mitochondrial membrane (IMM) is thought to involve two mitochondrial pyruvate carrier subunits, MPC1 and MPC2, assembled as a 150 kDa oligomeric heterotypic structure. We have demonstrated that homodimeric human MPC2 can promote efficient pyruvate transport into reconstituted proteoliposomes. Importantly, the derived funct…
Discovered by Hans Krebs nearly a century ago, the mitochondrial mammalian glutaminases proved highly complex enzymes in terms of primary sequence, leading to speculation about possible additional functions inside cells beyond their catalytic activity over the amino acid glutamine. Mammalian contain two distinct but structurally related genes coding for at least three different isoenzymes…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 7 / 7 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 21 / 16 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 36 / 31 | All research grants and scholarships |
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