CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Faculdade de Ciências Agrárias e Veterinárias (FCAV) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Dr Luciane Gargaglioni holds a degree in Biological Sciences from the Faculty of Philosophy, Sciences and Letters of Ribeirão Preto / USP (1994), master's degree in Physiology from the Faculty of Medicine of Ribeirão Preto, University of São Paulo (1998), Ph.D. Sandwich - University of British Columbia (2000, Canada) and PhD in Physiology, University of São Paulo at Ribeirão Preto Medical School (2002). She has a postdoctoral degree at the University of Calgary (Canada) and the Center national de la recherche scientifique (France). She is currently adjunct professor at FCAV / Unesp. She has experience in Physiology, focusing on Respiratory Physiology and Comparative Physiology, acting on the following subjects: hypoxia, hypercapnia, sexual dimorphism, prenatal stress, ventilation, thermoregulation, locus coeruleus, serotonin, development. Manuela´s mother. (Source: Lattes Curriculum)
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This proposal aims to finance an ongoing collaboration between FCAV/UNESP and McMaster University, enabling in-person meetings and knowledge exchange for both Principal Investigators (Prof. Luciane H. Gargaglioni and Prof. Graham R. Scott) and PhD students. This International Collaboration will not only facilitate learning cutting-edge techniques for the Regular Grant FAPESP (2024/20271-3…
High-altitude environments pose significant physiological challenges for bird species, marked by hypobaric hypoxia, cold temperatures, and elevated ultraviolet radiation. The main adaptations include modifications in the oxygen transport cascade, thermoregulation, and metabolic rates. This study aims to explore the physiological and behavioral adaptations of three different populations of…
Our group, composed of cardiorespiratory and thermal regulation physiologists in vertebrates, from the Interinstitutional Postgraduate Program in Physiological Sciences (PIPGCF - UFSCAR/UNESP), has strongly contributed to clarifying the homeostatic mechanisms involved in physiological adjustments in the face of disturbances in blood gases , thermal challenges and inflammatory responses, s…
(Only some records are available in English at this moment)
To maintain and modulate the homeostasis and vital functions, vertebrates depend on oxygen. Despite that, freshwater turtles are able to tolerate oxygen depletion conditions, anoxia, by lowering their metabolic rate drastically. In the environment, these anoxic periods, that are dependent on temperature, can endure up to forty days. The cellular metabolism of turtles changes from an aerob…
The first third of the incubation is determinant for the embryonic development and the temperature considered one of the most important factors, since small fluctuations of this parameter can affect the quality and the survival rate of the embryos. The goal of this proposal will be to investigate the effects of thermal manipulation during incubation on metabolism, body temperature, ventil…
(Only some records are available in English at this moment)
High-altitude environments pose significant physiological challenges for bird species, marked by hypobaric hypoxia, cold temperatures, and elevated ultraviolet radiation. The main adaptations include modifications in the oxygen transport cascade, thermoregulation, and metabolic rates. This study aims to explore the physiological and behavioral adaptations of three different populations of…
The brain covers a small fraction of the total body mass (~2%) but consumes up to 20% of the oxygen in the body and is a major producer of free radicals/reactive oxygen species (ROS). Due to low levels of antioxidants, auto-oxidation of neurotransmitters and the fact that neurons are rich in polyunsaturated fatty acids, this makes them more prone to lipid peroxidation, making this organ p…
Air temperatures on Earth have been rising since the Industrial Revolution. Although natural variability plays some role, the preponderance of evidence indicates that human activities, especially emissions of heat-trapping greenhouse gases, are primarily responsible for making our planet hotter. Other human actions have a negative effect on the environment, such as deforestation, pollutio…
Noradrenergic neurons located in the locus coeruleus (LC) play a crucial role in respiratory control, stress response and regulation of the sleep-wake cycle. This region is recognized as one of the main centers involved in the promotion of vigil. In addition, studies have shown greater activation of this nucleus in animals that have experienced adversities in early life, such as neonatal …
(Only some records are available in English at this moment)
The locus coeruleus (LC) is considered the main noradrenergic cell group in the central nervous system and sends projections to many areas of the brain. This is one of the areas that stands out in the ventilatory response to CO2, where more than 80% of noradrenergic neurons are sensitive to CO2/pH. It is well known that changes in blood gas concentrations can disturb the emotional state. …
This project aims to investigate the role of astrocytes in the locus coeruleus (LC) in response to CO2 exposure, with a focus on sex-specific differences. Using genetically modified mice expressing the GCaMP6f calcium sensor in astrocytes, we will monitor astrocytic calcium dynamics during normocapnia and hypercapnia through Ca2+ time-lapse imaging. Additionally, we will employ the Smart-…
The locus coeruleus (LC) is a noradrenergic nucleus that exhibits sexual dimorphism and projects extensively throughout the brain, serving as the main source of central noradrenaline. Our research team was among the first to highlight the significance of the LC in mediating ventilatory and behavioral responses to CO2/pH in both male and female rodents. The chemosensitivity of these neuron…
Rhythmic breathing depends on populations of interneurons in the brainstem, forming a ventral respiratory column, but there are functionally important distinctions among these populations. One particularly important population is located in the pre-Bötzinger complex (preBötC) that contains Dbx1-derived neurons that constitute the rhythm-generating core for mammalian inspiratory rhythm. No…
Alzheimer's disease (AD) is a neurodegenerative disorder often associated with age, whose cognitive and neuropsychiatric manifestations result in progressive disability and eventual incapacitation. More than 70% of patients institutionalized with AD present respiratory dysfunctions and these problems may contribute or lead to cognitive decline. These respiratory impairments probably refle…
In mammals, gas exchange during uterine life is performed via placenta, however, neural and muscle components of the respiratory system must be functional at birth, allowing the generation of a rhythm that ensure an adequate pulmonary ventilation. A neuronal circuit in the brainstem generates the respiratory rhythm and shapes the motor pattern of each breath to meet metabolic, biomechanic…
(Only some records are available in English at this moment)
| 5 / 5 | Ongoing grants |
| 13 / 12 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 47 / 25 | Completed scholarships in Brazil |
| 3 / 3 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 74 / 51 | All research grants and scholarships |
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