CV Lattes
ORCID
He is graduate at Chemistry from Universidade Estadual de Campinas (1992), master's at Chemistry from Instituto Militar de Engenharia (1995) and Ph.D. at Chemistry from Universidade de São Paulo (2000), besides 2 postdoctoral stages - Universidade de São Paulo and Barcelona Biomedical Research Park - Spain (2010). Currently, is Associate Professor at the School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - FCFRP / USP, since 2007, where he teaches 3 courses of Graduation and 4 of Post-Graduate. In research, works in the area of Medicinal Chemistry, with emphasis on molecular modeling and QSAR in drug design, including additional enzymatic activity assays with ligands of different therapeutic targets, particularly in cancer, Alzheimer's disease, leishmaniosis and inflammatory diseases. He is coordinator of a current project of medicinal Chemistry in Leishmaniosis and Chagas´disease. He was Director and Vice-Director of two International projects funded by FAPESP and CNPq, as welll as one of the principal investigators (PI) of International project in collaboration with the Nottingham University (PROGRAMA CAPES/UNIVERSIDADE DE NOTTINGHAM - SELEÇÃO DE PROJETOS ESPECIAIS DE PESQUISA EM DRUG DISCOVERY). He is also one of the investigators of the Center for Research in Inflammatory Diseases -CRID, FAPESP, as well as of the Medicinal Chemistry Open Acess, SGC-UNICAMP (The Structural Genomics Consortium), and associate researcher of a current FAPESP thematic project. With the private sector, it has established and maintains a University-Company partnership, in the form of scientific advice to assess the toxicological potential of compounds of agrochemical interest, through QSAR (Quantitative Structure-Activity Relationships) and QSTR (Quantitative Structure-Toxicity Relationships) studies. He has 1 patent and 189 publications, including 157 papers, 28 chapters of Medicinal Chemistry, as well as he is editor/co-editor of 4 international books in the field of Medicinal Chemistry. (Source: Lattes Curriculum)
- Computational design and biological evaluation of new proteasoma inhibitors, with interest in leishmaniosis and Chagas Disease, AP.R
Abstract
Neglected tropical diseases are a subset of infectious diseases reaching the poorest populations, most notably Chagas disease, African Trypanosomiasis and Leishmaniasis. The investment in the discovery of new drugs for these diseases is far below what is necessary, in the specific case of Leishmaniosis, the drugs that are commercially available in addition to the high cost, have undesir...
- Open-acess Medicinal Chemistry Centre (OpenMedChem), AP.TEM
Abstract
Many of the discoveries from the rapidly expanding genomic sciences are not effectively utilized in medicine, agriculture and industry. This is partly because of the disconnection between scientists in different disciplines, and because much of the translational research done in both industry and academia is patent-protected and not published in a timely manner. This INCT proposal addre...
- CRID - Center for Research in Inflammatory Diseases, AP.CEPID
Abstract
Inflammatory diseases are a complex and heterogeneous group of diseases that affect more than 10% of the word population. The current options for the treatment of these diseases are still limited and in some cases, inefficient due to limited understanding of the mechanisms underlying these diseases. The development of translational research by a center that can generate scientific knowl...
- XXV EFMC International Symposium on medicinal chemistry, AR.EXT
- Design and development of new potential anti-Alzheimer's agents based on the inhibition of acetylcholinesterase and glycogen synthase kinase 3-beta and anti-aggregation of the amyloid beta-peptide, AP.R
Abstract
Alzheimer's disease (AD), despite its high prevalence and impact, still has no cure, constituting currently drug therapies as the main hope for disease control. Thus, there is a continued need for the discovery and design of new drugs, in order to enrich the arsenal of substances available for pharmacotherapy, whether inhibitors of acetylcholinesterase (AChE), glycogen synthase kinase 3...
- VIIIth Congress of the International Society of Theoretical Chemical Physics, AR.EXT
(Only some records are available in English at this moment)
- Planning of new candidates for anti-inflammatory drugs, BP.PD
Abstract
Some of the main therapeutic targets previously selected for the design of drug candidates in inflammatory diseases will be investigated with the use of different methodologies of Computational Medicinal Chemistry. The candidate has experience and he will work with ligand- and structure-based drug design (of the targets here investigated). (AU)
- Planning, development and pharmacological evaluation of new aryl hydrocarbon receptors (AhR) antagonists that are candidates for atheroprotective drugs, BP.PD
Abstract
Cardiovascular diseases result from atherosclerotic lesions and account for 31% of the world mortality. A major risk factor for atherosclerosis is smoking, which enhances the atherogenic process upon the activation of aryl hydrocarbon receptors (AhR) evoked by cigarette smoke contaminants. These receptors belong to the bHLH/PAS protein superfamily and induce the expression of pro-athero...
- Planning of new candidates for anti-inflammatory drugs design, BP.PD
Abstract
Some of the main therapeutic targets previously selected for the design of drug candidates in inflammatory diseases will be investigated with the use of different methodologies of Computational Medicinal Chemistry. The candidate will have notions of structure- and ligand-based drug design and molecular knowledge of the targets investigated, as well as first contacts with synthetic organ...
(Only some records are available in English at this moment)
- Development and validation of algorithm for search of bioactive conformations using three-dimensional grind and grind-2 descriptors, with application in 3d-qsar and virtual screening to design new anti-cancer agents, BE.NF
Abstract
In this project, it is proposed the development and validation of an algorithm for finding bioactive conformations using GRIND and GRIND-2 descriptors, which will allow 3D-QSAR models based on conformations of maximum similarity of a series of compounds, with high chemical information and high predictive power, independent of the degree of freedom, in a semi-automated, fast and reliable...
| 3 / 3 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 13 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 22 / 17 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 11 |
| Citations | 39 |
| Cit./Article | 3.5 |
| Data from Web of Science | |
RODRIGUES, RICARDO P.; DA SILVA, CARLOS H. T. P.. Discovery of potential neurodegenerative inhibitors in Alzheimer's disease by casein kinase 1 structure-based virtual screening. MEDICINAL CHEMISTRY RESEARCH, v. 26, n. 12, p. 3274-3285, DEC 2017. Web of Science Citations: 4. (10/14929-3)
PERNOMIAN, LARISSA; MOREIRA, JOSIMAR DORNELAS; GOMES, MAYARA SANTOS. In the View of Endothelial Microparticles: Novel Perspectives for Diagnostic and Pharmacological Management of Cardiovascular Risk during Diabetes Distress. JOURNAL OF DIABETES RESEARCH, 2018. Web of Science Citations: 0. (12/00640-7, 13/08216-2, 09/01005-0, 14/17740-0, 12/09019-3)
PERNOMIAN, LARISSA; DA SILVA, CARLOS H. T. P.. Current basis for discovery and development of aryl hydrocarbon receptor antagonists for experimental and therapeutic use in atherosclerosis. European Journal of Pharmacology, v. 764, p. 118-123, OCT 5 2015. Web of Science Citations: 6. (13/08216-2, 14/17740-0)
PERNOMIAN, LARISSA; DO PRADO, ALEJANDRO F.; GOMES, MAYARA S.; PERNOMIAN, LAENA; DA SILVA, CARLOS H. T. P.; GERLACH, RAQUEL F.; DE OLIVEIRA, ANA M.. MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS axis functionality. European Journal of Pharmacology, v. 764, p. 173-188, OCT 5 2015. Web of Science Citations: 11. (12/00640-7, 13/08216-2, 14/17740-0, 12/09019-3)
SANTOS, CLEYDSON B. R.; SANTOS, KELTON L. B.; CRUZ, JORDDY N.; LEITE, FRANCO H. A.; BORGES, ROSIVALDO S.; TAFT, CARLTON A.; CAMPOS, JOAQUIN M.; SILVA, CARLOS H. T. P.. Molecular modeling approaches of selective adenosine receptor type 2A agonists as potential anti-inflammatory drugs. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, MAY 2020. Web of Science Citations: 0. (14/11009-1)
PERNOMIAN, LARISSA; GOMES, MAYARA S.; TOMICH DE PAULA DA SILVA, CARLOS H.; ROSA, JOAQUIN M. C.. Reverse Induced Fit-Driven MAS-Downstream Transduction: Looking for Metabotropic Agonists. Current Medicinal Chemistry, v. 24, n. 39, p. 4360-4367, 2017. Web of Science Citations: 0. (12/00640-7, 13/08216-2, 14/17740-0, 12/09019-3)
MOREIRA, JOSIMAR D.; PERNOMIAN, LARISSA; GOMES, MAYARA S.; PERNOMIAN, LAENA; MOREIRA, RAFAEL P.; DO PRADO, ALEJANDRO F.; DA SILVA, CARLOS H. T. P.; DE OLIVEIRA, ANA M.. Acute restraint stress increases carotid reactivity in type-I diabetic rats by enhancing Nox4/NADPH oxidase functionality. European Journal of Pharmacology, v. 765, p. 503-516, OCT 15 2015. Web of Science Citations: 10. (11/11205-7, 14/17740-0, 13/08216-2)
PERNOMIAN, LARISSA; GIMENES, LILIAN R.; GOMES, MAYARA S.; DO VALE, BRUNO N.; CARDOSO, CRISTINA R. B.; DE OLIVEIRA, ANA M.; MOREIRA, JOSIMAR D.. Endothelinergic Contractile Hyperreactivity in Rat Contralateral Carotid to Balloon Injury: Integrated Role for ETB Receptors and Superoxide Anion. BIOMED RESEARCH INTERNATIONAL, 2017. Web of Science Citations: 0. (13/08216-2, 12/00640-7, 14/17740-0, 12/09019-3, 09/01005-0)
PERNOMIAN, LARISSA; GOMES, MAYARA SANTOS; MOREIRA, JOSIMAR DORNELAS; TOMICH DE PAULA DA SILVA, CARLOS HENRIQUE; CAMPOS ROSA, JOAQUIN MARIA; DE BARROS CARDOSO, CRISTINA RIBEIRO. New Horizons on Molecular Pharmacology Applied to Drug Discovery: When Resonance Overcomes Radioligand Binding. CURRENT RADIOPHARMACEUTICALS, v. 10, n. 1, p. 16-20, 2017. Web of Science Citations: 0. (12/00640-7, 14/17740-0, 12/09019-3)
PERNOMIAN, LARISSA; GOMES, MAYARA S.; PERNOMIAN, LAENA; MOREIRA, RAFAEL P.; CORREA, FERNANDO M. A.; DE OLIVEIRA, ANA M.. Vasoprotective effects of neurocompensatory response to balloon injury during diabetes involve the improvement of Mas signaling by TGF beta(1) activation. VASCULAR PHARMACOLOGY, v. 64, p. 36-48, JAN 2015. Web of Science Citations: 5. (12/00640-7, 13/08216-2, 09/01005-0, 11/11205-7, 14/17740-0)
PERNOMIAN, LARISSA; PERNOMIAN, LAENA; GOMES, MAYARA S.; DA SILVA, CARLOS H. T. P.. Pharmacological significance of the interplay between angiotensin receptors: MAS receptors as putative final mediators of the effects elicited by angiotensin ATi receptors antagonists. European Journal of Pharmacology, v. 769, p. 143-146, DEC 15 2015. Web of Science Citations: 3. (12/00640-7, 13/08216-2, 11/11205-7, 14/17740-0)
(References retrieved automatically from State of São Paulo Research Institutions)
ALMEIDA, Jonathan Resende de. Estudos de modelagem molecular e relação estrutura-atividade da acetilcolinesterase e inibidores em Mal de Alzheimer. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (08/07248-0)
SEMIGHINI, Evandro Pizeta. Planejamento racional de inibidores da beta-secretase em mal de Alzheimer. Tese (Doutorado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (08/10805-8)
ALMEIDA, Jonathan Resende de. Planejamento, ensaio e otimização in silico de novos protótipos inibidores da enzima acetilcolinesterase. Tese (Doutorado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (11/01328-4)
SILVA, Vinicius Barreto da. Modelagem molecular, síntese e avaliação da atividade biológica de potenciais antineoplásicos com a proteína hnRNP K e culturas de células tumorais. Tese (Doutorado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (07/07934-8)
RODRIGUES, Ricardo Pereira. Caseína quinase 1 como alvo para o planejamento de fármacos em mal de Alzheimer. Tese (Doutorado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (10/14929-3)