CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Centro de Terapia Celular e Molecular (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas from Universidade Presbiteriana Mackenzie (1995) and doctorate at Immunology from Universidade de São Paulo (2003). Has experience in Immunology, acting on the following subjects: macrófagos, flagelina, interleucina-12, plasmodium chabaudi and trypanosoma cruzi. (Source: Lattes Curriculum)
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Several viruses have the ability to invade the Central Nervous System (CNS), infecting resident cells and causing severe neuroinflammation by activating the innate immune system. Exacerbated inflammatory responses are influenced by the activation of inflammasomes, which are multiprotein platforms present in the cytosol of different cell types capable of activating the caspase-1 protease, …
The intracellular protozoan Trypanosoma cruzi is the causative agent of Chagas disease, a serious and chronic pathology that affects millions of people worldwide. It is known that control of T. cruzi infection requires the actions of multiple mechanisms of innate immunity that are triggered by pattern recognition receptors (PRRs). Recently, our group demonstrated the involvement of NLRP3 …
Autophagy is a homeostatic process by which misfolded proteins and damaged organelles are degraded. Autophagy also contibutes to degrade macromolecules under starvation. In infectious processes, autophagy helps to control microorganisms by deliverying them to degradation in autolysosomes. Pattern recognition receptors (PRRs) have been related to the regulation of autophagy. Toll-like rece…
(Only some records are available in English at this moment)
Several viruses have the ability to invade the Central Nervous System (CNS), which can infect resident cells and cause severe neuroinflammation by activating the innate immune system. It is known that these highly inflammatory processes are influenced by the activation of inflammasomes, which are multiprotein platforms present in the cytosol of different cell types, capable of activating …
Toxoplasma gondii is an obligate intracellular parasite and is responsible for causing the disease Toxoplasmosis, which can present several serious clinical manifestations and even lead immunocompromised patients to death. T. gondii is the major protozoan neurotrophism model, being widely observed in its latent form (cysts) in cells of the Central Nervous System (CNS). The control of T. g…
Toxoplasma gondii is an obligate intracellular parasite that causes Toxoplasmosis, a disease that can be fatal for immunocompromised or newborns of infected mothers. Several defense mechanisms mediated by innate immunity have already been described in resistance to the parasite, including mechanisms mediated by inflammasomes. Inflammasomes are caspase-1 activating multiprotein platforms, …
The Zika virus (ZIKV) is an Arbovirus belonging to the family Flaviviridae of the genus Flavivirus, described for the first time in 1974 in Uguanda. In 2007, the transmission by the Aedes aegypti mosquito caused the first epidemic in Micronesia, leading to a worldwide warning about the severity of the symptoms by infected individuals. In 2013, the ZIKV spread through Brazil and others Lat…
Inflammasomes are high-molecular-weight multiprotein complexes present in the cell cytosol. Different inflammasomes can be assembled, and vary according to their protein composition and the nature of the ligands. However, despite this diversity, the central effector mechanism of the activated inflammasomes is the conversion of the pro-caspase-1 in caspase-1. In turn, caspase-1 cleaves gas…
(Only some records are available in English at this moment)
Inflammasomes are molecular complexes that detect sterile or infectious stimuli and trigger caspase-1 activation, leading to the release of IL-1² and IL-18 and cell death by pyroptosis. NLRP3 is assembled in response to pathogenic microorganisms and sterile signals, while NAIP/NLRC4 is classically activated by bacterial protein that reaches the cytosol, such as flagellin. In different con…
Flagellin is an agonist of TLR and NLR receptors that has been extensively investigated as an adjuvant. Innate immune recognition of flagellin is shared by transmembranic TLR5 and cytosolic Naip5/NLRC4 inflammasome complex. We have demonstrated a process of necrotic cell death induced by cytosolic flagellin that does not require NLRC4, ASC or caspase-1/11 but it is regulated by lysosomal …
The discovery of two large families of receptors that recognize a range of molecular patterns associated with pathogens, was of great importance for the understanding of recognition mechanisms mediated by innate immunity cells. These two families which include the transmembrane Toll-like receptors (TLRs) and cytoplasmic receptors, NOD-like receptors (NLRs), although induce distinct respon…
| 1 / 1 | Ongoing research grants |
| 8 / 8 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 19 / 15 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 33 / 29 | All research grants and scholarships |
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