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Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Dr. Luis L.P. da Silva holds a Bachelors degree in Pharmacy (1999) and a Masters degree (2002) from the University of São Paulo, Brazil, and earned his PhD from the University of Leeds, UK, in 2006. From 2006 to 2009, he was a visiting postdoctoral fellow at the NICHD, National Institutes of Health (NIH), in Bethesda, MD, USA. He is currently an Associate Professor of Cell Biology at the Ribeirão Preto Medical School, University of São Paulo. Dr. da Silvas research investigates the molecular mechanisms governing protein trafficking in the cellular endomembrane system and explores how enveloped viruses especially HIV and bunyaviruses subvert these pathways to facilitate their replication and pathogenesis. (Source: Lattes Curriculum)
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Electron microscopy (EM) is a crucial tool in basic and clinical studies in biomedicine, allowing the detailed visualization of cellular and molecular structures at nanometric scales. The evolution of the technique includes cryo-electron microscopy (Cryo-EM), which preserves samples in their native state, enabling 3D electron microscopy, which reconstructs three-dimensional structures. 3D…
The emergence of life diversity and complexity has been facilitated by intercellular communication, which is partially supported by a highly conserved pathway known as the conventional secretory pathway. This pathway involves the secretion of proteins containing a signal peptide through the endoplasmic reticulum-Golgi apparatus-final destination route. Although some questions remain open,…
The Zika virus (ZIKV) and the Oropouche virus (OROV) are emerging arboviruses of great importance to public health, and due to global climate changes, they have the potential to spread to new tropical and subtropical regions. While ZIKV caused a severe epidemic in Brazil, OROV causes recurrent and recent outbreaks in the Caribbean and tropical regions of Latin America. Both viruses, despi…
(Only some records are available in English at this moment)
Although dispensable for HIV replication in vitro, the Nef viral protein is critical for maintaining high viral loads in animal models and progression to AIDS in human patients. Nef interferes with the intracellular transport of host proteins involved in the virus replicative cycle and immunity. Among the targets of Nef is the SERINC5 protein, which, when incorporated into nascent viral p…
The HIV-1 accessory protein Nef downregulates cell surface expression of MHC-I molecules to facilitate virus spreading. The Nef-induced downregulation of MHC-I molecules, such as HLA-A, requires the clathrin adaptor protein 1 (AP-1) complex. The cooperative interaction of Nef, AP-1, and the cytosolic tail (CT) of HLA-A leads to redirection of HLA-A targeting from the trans-Golgi network (…
Oropouche virus (OROV) is one of the most common arboviruses that infects humans in South America. A conservative estimate is that half million people have been infected by OROV in Brazil since the virus was first identified in 1955, although this is likely to be an underestimate due to a resemblance of Oropouche fever with the symptoms of other arbovirus infections including Dengue, Zika…
(Only some records are available in English at this moment)
The Oropouche virus (OROV) is a member of the Peribunyaviridae family within the order Bunyavirales and is responsible for causing Oropouche fever, a disease with significant impact in several countries in Central and South America. In the first half of 2024, there was a marked increase in the number of Oropouche fever cases in Brazil, with autochthonous reports in almost all states, incl…
The Oropouche virus (OROV) is an enveloped virus with a genome composed of three RNA segments, encoding four structural proteins (N, RdRp, Gn, and Gc) and two non-structural proteins (NSm and NSs). OROV is the causative agent of Oropouche fever, a febrile illness affecting Brazil and several other countries in South and Central America. Recent cases suggest that viral infection may be ass…
(Only some records are available in English at this moment)
The interactions between viral factors and the host cell endomembrane system are of fundamental importance for the replication and pathogenesis of SARS-CoV-2. The assembly and externalization of CoVs involve: 1) the invagination of the limiting membrane of the ER-Golgi intermediate compartment (ERGIC) with the consequent budding of nascent viral particles into its interior and 2) the fusi…
(Only some records are available in English at this moment)
The adaptor protein (AP) complexes are heterotetrameric complexes that coordinate protein trafficking in the endocytic and secretory pathways. AP-1, a complex of four distinct subunits (gamma, beta1, mi1, and sigma1), is thought to mediate protein trafficking between the trans-Golgi network (TGN) and endosomes and Lysosomes Related Organelles (LROs) though clathrin-coated vesicles (CCV). …
The Oropouche virus (OROV) is the etiological agent of Oropouche fever, a debilitating febrile illness common in South America. Despite its importance in public health, little is known about the biology of the virus in the host cell, especially the relationship between viral and cellular host protein. Our preliminary results from mass spectrometry analysis of the cellular proteome during …
The HIV-1 envelope comprises plasma membrane-derived lipids with inserted viral glycoproteins trimers and host membrane proteins. This complex assembly process is mainly orchestrated by HIV-1 Gag, a structural protein that is key to organize viral assembly and budding domains at the plasma membrane. The interferon-induced transmembrane protein 3 (IFITM3) is a host antiviral protein that m…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing grants |
| 12 / 7 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 38 / 30 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 66 / 53 | All research grants and scholarships |
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