CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Bacharel em Química - Modalidade tecnológica from Universidade de São Paulo (1992), master's at Química Analítica from Universidade de São Paulo (1995) and ph.d. at Bioquimica [SP] from Universidade de São Paulo (2001). Has experience in Biochemistry, focusing on Biochemistry, acting on the following subjects: y1 adrenocortical cells, acth, signal transduction, acth-r and cell cycle. (Source: Lattes Curriculum)
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Glioblastoma multiforme (GBM) is the most aggressive brain tumor that grows and spreads quickly. Its malignancy is also due to high resistance to conventional therapies, poor prognosis and high post-therapy recurrence rate with survival of only 1-2 years. Previous work by the group contributed to new proposals for molecular targets that offer an advantage in pre-sensitizing tumor cells an…
A better understanding on the mechanisms of action of tyrosine phosphatase DUSP12 can identify potential correlations with cellular disorders and suggest strategies of intervention on its enzymatic activity, unveiling it as a drug target of clinical interest. This dual-specificity tyrosine phosphatase (DUSP) is known to preferentially dephosphorylate phospho-tyrosine - but also phospho-se…
Since the last five years our laboratory investigates the participation of enzymes of the Rho GTPases and the dual-specificity phosphatase (DUSP) families in mechanisms of genomic stability maintenance that provide to the cells resistance and/or sensitivity to genotoxic agents. For example, we have shown the involvement of the DUSP3 (or VHR) in the repair of DNA damage induced by gamma io…
The high expression and nuclear activity of protein phosphatases is mostly attributed to the serine / threonine phosphatases (S/TP). Only a few protein tyrosine phosphatases (PTP) acting on nuclear biochemical and biological events have been characterized. One of the PTP sub- families whose substrates are very diverse and little explored is the dual specificity phosphatases (DUSP), more s…
(Only some records are available in English at this moment)
Changes in the nucleus of cancer cells are frequent and widely used in the diagnosis and prognosis of cancer patients, since that have been related to tumor aggressiveness, invasion and metastasis. Emerin is a nuclear membrane protein that plays an important role in the integrity of the nuclear architecture ando also important for gene expression, cell signaling, and chromatin organizatio…
Protein tyrosine phosphatases (PTPs) act by dephosphorylating tyrosine residues in different biomolecules and, therefore, their activity regulates the course of cellular processes physiologically essential. Dual-specificity PTPs (DUSPs) can dephosphorylate tyrosine and threonine/serine residues, thus acting on a greater variety of substrates and, consequently, being involved in several di…
Protein tyrosine phosphatases (PTPs) catalyze the removal of phosphate groups from tyrosine residues in proteins and modulate the activity of their substrates. Approximately half of PTPs correspond to dual-specific protein tyrosine phosphatases (DUSPs), in which the catalytic activity also encompasses phosphoserine or phosphothreonine residues. In recent years, the involvement of DUSPs in…
(Only some records are available in English at this moment)
Glioblastoma multiforme (GBM) is the most aggressive and frequently diagnosed type of brain tumor among glioma subtypes. The treatments begin with radio and chemotherapy and, when it's possible, with the surgical resection of the tumor before or as an adjunct to the treatments. In addition to ionizing gamma radiation (IR), the main drug used in chemotherapy against these tumors is the te…
The human genome expresses about 100 functional tyrosine phosphatase enzymes (PTKs) that preferentially dephosphorylate tyrosine residues - but also tyrosine/serine or tyrosine/threonine - phosphorylated on protein substrates and other phospho-biomolecules. Some members of this class have increased protein expression levels in certain types of human tumors such as mammary, cervical, color…
(Only some records are available in English at this moment)
Protein tyrosine phosphatases (PTPs) regulate signaling and other biochemical processes through dephosphorylation of proteins at the tyrosine residue; disruption of their functioning may lead to serious diseases and disorders. Within the class I of cysteine-based PTPs, PTPRC (or CD45) is a prototype of the entire superfamily and identified as the initial link between phosphatases and the …
This project aims to study the molecular involvement of dusp12 gene in mouse embryonic fibroblasts (MEp) isolated and established from dusp12 gene targeted mouse. The absence of dusp12 gene in cell cycle control proliferation and migration of MEF lines will be investigated. DUSP12 protein expression will be checked as well as phosphorylation (activation) of MAPKs in parental MEFs ou isola…
| 1 / 1 | Ongoing grants |
| 7 / 5 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 14 / 9 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 28 / 21 | All research grants and scholarships |
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