CV Lattes
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ORCID
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciencias Biologicas - Modalidade medica from Universidade Federal de São Paulo (2000) and doctorate at Microbiology from Universidade Federal de São Paulo (2005). Has experience in Immunology, focusing on Immunology, acting on the following subjects: células b-1, macrofago, diferenciação, fagocitose and gp43 paracoccidioides brasiliensis. (Source: Lattes Curriculum)
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Chronic Lymphocytic Leukemia (CLL) is the most common form of hematological cancer in adults, particularly in individuals over the age of 50. CLL is characterized by the accumulation of clonal B lymphocytes that are resistant to apoptosis and exhibit a phenotype similar to B-1 cells. Studies show that resistance to apoptosis in CLL cells is associated with defective regulation of anti-apo…
miRNA deregulation appears in neoplastic conditions, including hematological diseases. Decreased levels of miR-15a/16 are shown in the human Chronic Lymphocytic Leukemia (CLL) and also in disease-murine models, where both present apoptosis-resistant cells with increase in BCL-2 expression, an anti-apoptotic molecule regulated by miR-15a/16. In CLL, failures in apoptosis system correlates …
Senescence is a normal biological process that occurs in all organisms and involve a decline in cell functions. The effects of aging on the immune system affect the production and function of B and T lymphocytes. Besides implications of immunosenescence on the susceptibility to infectious diseases, this also implicates in the increase of hyperproliferative diseases, such as autoimmune dis…
Ikaros is considered an important regulator of lymphoid development and differentiation. Several reports reinforce the hypothesis that Ikaros expression is deregulated in human leukemias. It has been suggest the role of Ikaros in the regulation of the transcription of genes that are involved in the BCR signaling. The absence of Ikaros is in detrimental for activation of BCR signals. The I…
Accumulation of mutations and changes in the immune system could happen in aging, for example, due to environmental pressures. It was seen that there is an accumulation of B-1 cells in bone marrow and lymphoid organs of old mice and our group showed that the B-1 cell progenitor (B-1p - Lin-CD45R-CD19+CD93+) population increases in the bone marrow of healthy old C57Bl/6 mice (with 30 weeks…
The immune system is influenced by the stage of life and lifestyle of the individual. Immunosenescence is a physiological process that can lead to structural and functional changes in the immune system. Practicing physical exercise is an external factor to the inevitable internal process of aging by the immune system, which is capable of generating changes in its functioning. T and B Lym…
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD5+ B cells in lymphoid organs and peripheral blood. The incidence is high in people over 50 years of age and its prognosis is quite diverse, also affecting treatment. Several therapies are currently in use but, in some cases, there may be resistance and disease relapsing, which demands a search for new alternativ…
The appearance of hyperproliferative diseases, such as chronic lymphocytic leukemia (CLL), is directly related to problems in the process of apoptosis of cells as well as to the immunosenescence brought about with the advancing age of an individual. Studies have shown that with age there is an increase in the population of B-1 cells (cell type found in this disease). This leads to the hyp…
(Only some records are available in English at this moment)
B cell development represents a very orchestrated pathway that initiates with hematopoietic stem cells resulting in mature B lymphocytes, which will participate in immunological responses. The genetic program for this lymphopoiesis differs between fetal and adult human samples and is regulated by several molecules, including microRNAs. The axis formed by the microRNA Let7 and its regulato…
| 1 / 1 | Ongoing grants |
| 6 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 15 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 24 / 16 | All research grants and scholarships |
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